نتایج جستجو برای: tspo

تعداد نتایج: 1222  

2017
Ségolène Hescot Larbi Amazit Marie Lhomme Simon Travers Anais DuBow Stephanie Battini Geoffrey Boulate Izzie Jacques Namer Anne Lombes Anatol Kontush Alessio Imperiale Eric Baudin Marc Lombes

Mitotane (o,p'DDD), the most effective drug in adrenocortical carcinoma, concentrates into the mitochondria and impacts mitochondrial functions. To address the molecular mechanisms of mitotane action and to identify its potential target, metabolomic and lipidomic approaches as well as imaging analyses were employed in human adrenocortical H295R cells allowing identification of Mitochondria-Asso...

2016
Tamara Azarashvili Olga Krestinina Yulia Baburina Irina Odinokova Vladimir Akatov Igor Beletsky John Lemasters Vassilios Papadopoulos

The translocator protein (TSPO; 18 kDa) is a high-affinity cholesterol-binding protein located in the outer membrane of mitochondria. A domain in the C-terminus of TSPO was characterized as the cholesterol recognition/interaction amino acid consensus (CRAC). The ability of the CRAC domain to bind to cholesterol led us to hypothesize that this peptide may participate in the regulation of mitocho...

2015
Miklós Tóth Janine Doorduin Jenny Häggkvist Andrea Varrone Nahid Amini Christer Halldin Balázs Gulyás Kenji Hashimoto

UNLABELLED Molecular imaging of the 18 kD Translocator protein (TSPO) with positron emission tomography (PET) is of great value for studying neuroinflammation in rodents longitudinally. Quantification of the TSPO in rodents is, however, quite challenging. There is no suitable reference region and the use of plasma-derived input is not an option for longitudinal studies. The aim of this study wa...

2014
Maria-Joao Ribeiro Johnny Vercouillie Severine Debiais Jean-Philippe Cottier Isabelle Bonnaud Vincent Camus Samuel Banister Michael Kassiou Nicolas Arlicot Denis Guilloteau

BACKGROUND Cerebral stroke is a severe and frequent condition that requires rapid and reliable diagnosis. If administered shortly after the first symptoms manifest themselves, IV thrombolysis has been shown to increase the functional prognosis by restoring brain reperfusion. However, a better understanding of the pathophysiology of stroke should help to identify potential new therapeutic target...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2014
Emma R O'Brien Veerle Kersemans Matthew Tredwell Begona Checa Sébastien Serres Manuel Sarmiento Soto Veronique Gouverneur David Leppert Daniel C Anthony Nicola R Sibson

UNLABELLED Metastatic spread of cancer cells to the brain is associated with high mortality, primarily because current diagnostic tools identify only well-advanced metastases. Brain metastases have been shown to induce a robust glial response, including both astrocyte and microglial activation. On the basis of these findings, we hypothesized that this stromal response may provide a sensitive bi...

Journal: :European Biophysics Journal 2020

Journal: :Nature Structural & Molecular Biology 2015

Journal: :Clinical and Translational Imaging 2015

Journal: :Journal of the Endocrine Society 2020

Journal: :Science 2015
Jimin Wang

Li et al. (Reports, 30 January, p. 555) reported on a crystal structure for a translocator protein (TSPO) from Rhodobacter sphaeroides in which some of the electron density is modeled as a porphyrin. The analysis of the x-ray data discussed here suggests that this assignment is incorrect.

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