Türkiye’nin ?dari te?kilat?na tarihsel anlamda bak?ld???nda Kamu Yönetiminin, sürekli olarak çe?itli paradigma de?i?iklikleri ile gerçekle?en sistem dönü?ümlerine u?rad??? görülmektedir. Söz konusu de?i?iklikler genel sistemin ana unsurlar?n? düzenlerken üst normlarda yap?lan de?i?ikliklerin zamanla ikincil mevzuata tatbik edilmeye çal???ld??? da anla??lmaktad?r. Ancak bu süreçte meydana gelen ...

The inhibition of thymidylate synthase (TS) by the 5-fluorouraciI (5FU) metabolite 5-fluorodeoxyuridine monophosphate can be biochem ically modulated by leucovorin (LV). LV administration increases the level of reduced folates in tissues, which promotes the inhibition of TS. We have studied the antitumor effect, free 5-fluorodeoxyuridine monophosphate levels, and inhibition of TS in two murine ...

The inhibition of thymidylate synthase (TS) by the 5-fluorouraciI (5FU) metabolite 5-fluorodeoxyuridine monophosphate can be biochem ically modulated by leucovorin (LV). LV administration increases the level of reduced folates in tissues, which promotes the inhibition of TS. We have studied the antitumor effect, free 5-fluorodeoxyuridine monophosphate levels, and inhibition of TS in two murine ...

PURPOSE Despite adjuvant 5-fluorouracil (5-FU) therapy, approximately 30% of patients with International Union against Cancer stage II and III colorectal cancer develop recurrence. In this study, we determined the prognostic value of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) expression in colorectal cancer patients treated with adjuvant 5-FU. EXPERIMENTAL DESIGN A re...

Thymidylate synthase (TS) is responsible for the de novo synthesis of thymidylate, which is required for DNA synthesis and repair and which is an important target for fluoropyrimidines such as 5-fluorouracil (5-FU), and antifolates such as Tomudex (TDX), ZD9331, and multitargeted antifolate (MTA). To study the importance of TS expression in determining resistance to these agents, we have develo...

Persistent reovirus infection of L cells was established with a serially passaged stock of temperature-sensitive (ts) mutant C(447) containing greater than 90% defective interfering particles. Within a month after establishment of the carrier culture, the ts mutant was replaced by virus that expressed the wild-type (ts(+)) temperature phenotype (R. Ahmed and A. F. Graham, J. Virol. 23:250-262, ...

The Trypanosoma cruzi trans-sialidase (TS) is a unique enzyme with neuraminidase and sialic acid transfer activities important for parasite infectivity. The T. cruzi genome contains a large family of TS homologous genes, and it has been suggested that TS homologues provide a mechanism of immune escape important for chronic infection. We have investigated whether the consensus TS enzymatic domai...

Recently, we have demonstrated that thymidylate synthase (TS) protein expression predicts for the clinical response to a regimen of infusional 5-fluorouracil (5FU) in advanced colorectal cancer patients. Previous studies by other groups that showed a correlation between TS gene expression and response to the fluoropyrimidine also involved infusional regimens. Considering the putatively differen...

The experiment was laid out at Agricultural College and Research Institute, Madurai, Tamil Nadu. India and the materials for this study consisted of three TGMS lines viz., TS 29, TS 6 and GD 98013 and 11 testers viz., ADT 39, ADT 41, Pusa Basmathi 1, Basmathi 370, Improved White ponni, AD 98028, GEB 24, ADT 43, ADT 45, Taroari Basmathi and Jeeraga samba. Crossing was done according to clipping ...