BACKGROUND Chromogenic anti-factor Xa activity (AXA) assay is reported to be the most appropriate method to measure the pharmacodynamics of apixaban, but the distribution of AXA in non-valvular atrial fibrillation (NVAF) patients on apixaban therapy has not been fully elucidated. METHODSANDRESULTS Steady-state trough and peak AXA were measured in 124 NVAF patients taking apixaban. In 25 patie...

The remote and often ice-covered Amundsen Sea Embayment in Antarctica is important for transporting relatively warm modified Circumpolar Deep Water (mCDW) to the Western Antarctic Ice Sheet, potentially accelerating its thinning contribution sea level rise. To investigate potential pathways variability of mCDW, 3809 CTD profiles (instrumented seal ship-based data) are classified using a machine...

BACKGROUND AND AIMS Antibodies to infliximab reduce serum infliximab with loss of clinical benefit, but undetectable trough serum concentrations of infliximab may occur without antibody formation. The relationship between trough serum infliximab and clinical outcomes was evaluated in acute ulcerative colitis. METHODS In a cohort of 115 patients with ulcerative colitis treated with three-dose ...

To validate the abundance of scenarios of large earthquakes in the Nankai Trough, we examined the effects of both lateral and vertical expansions of the source areas on maximum tsunami heights along the Pacific coast and Seto Inland Sea. The recently proposed Nankai Trough earthquake scenario (Mw = 9) has a maximum slip of 20 m near the trough axis. However, the predicted tsunami heights exceed...

An evacuated tube solar collector using therminol D-12 as heat transfer fluid coupled with parabolic trough is studied in this paper. An experimental set-up was constructed to study the performance of evacuated tube collector with therminol D-12 as heat transfer fluid. The parabolic trough is coupled with evacuated tube collector for better performance. In the traditional solar collectors water...