The aim of this study was to investigate the influence of pH, buffer species and ionic strength on the release mechanism of Glipizide (G) from matrix tablets containing chitosan and xanthan gum prepared by a hot-melt extrusion process. The release mechanisms were controlled by the solubility and ionic properties of the polymers. All directly compressed (DC) tablets prepared in this study also e...

Administer tablets and capsules with water on an empty stomach, preferably one-half hour to an hour before breakfast. Administer four hours apart from antacids, iron, and calcium supplements (Prod Info Tirosint oral capsules, 2006; Prod Info Synthroid oral tablets, 2005; Prod Info Levoxyl oral tablets, 2004). Levothyroxine tablets may be crushed and suspended in 5 to 10 milliliters of water pri...

Despite the advances made in the recording and cataloguing of cuneiform tablets, there is still much work to be done in the field of cuneiform reconstruction. The processes employed to rebuild cuneiform fragments still rely on glue and putty, with manual matching of fragments from catalogues or individual collections. The reconstruction process is hindered by inadequate information about the si...

Tablet splitting is an accepted practice for the administration of drugs for a variety of reasons, including dose adjustment, ease of swallowing and cost savings. The purpose of this study was to evaluate the physical properties of lisinopril tablets as a result of splitting the tablets either by hand or with a splitting device. The impact of the splitting technique of lisinopril (Zestril® tabl...

Introduction: To investigate the dosing accuracy using split tablets in paediatric patients. Methods: Five brands of tablets (Alvedon® (paracetamol), Catapresan® (clonidine), Hydrocortone® (hydrocortisone), Prednisolon® (prednisolon) and Tavegyl® (clemastine) were split into halves and quarters by hand or by using a tablet splitter. The resulting halves and quarters were weighed. Results: Three...

This report describes a new disintegration tester that can determine not only the disintegration time of orally rapidly disintegrating tablets (ODT), but also the disintegration behavior and mechanism. Using the tester, the disintegration properties of the tablets prepared in a previous study were examined. The purpose of this study is to confirm the utility of the tester as an instrument for e...

aIms: There has been a considerable increase in the number of seizures of amphetamine-type stimulant (ATS) tablets in Japan. The ATS tablets contain one or more of active ingredients, which include 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxyethylamphetamine (MDEA), methamphetamine (MA), etc.. In addition, the tablets often contain other comp...

Albizia gum has been evaluated as a binding agent in tablet formulations in comparison with gelatin BP. Compressional properties were analyzed using density measurements and the compression equations of Heckel and Kawakita as assessment parameters, while the mechanical properties of the tablets were assessed using the crushing strength and friability of the tablets. Drug release properties of t...

The aim of this study was to investigate swelling and erosion behaviors of hydrophilic matrix tablets using pectin and their impact on drug release. The matrix tablets were prepared by direct compression using different types of pectin. Swelling and erosion studies of pectin matrix tablets were carried out in various media. The pectin matrix tablets formed a continuous gel layer while in contac...

Isothermal heat conduction microcalorimetry was used to evaluate chemical stability of a solid drug in tablets. A variety of mixtures were compressed to flat faced tablets of 300 mg weight and 10 mm diameter. The content of drug amounted to 10%. Besides drug containing tablets, also placebo tablets as well as the non compressed mixtures were examined by microcalorimetry at 80 degrees C. The exc...