نتایج جستجو برای: trkb

تعداد نتایج: 2355  

2014
Alberto Jiménez-Maldonado Elena Roces de Álvarez-Buylla Sergio Montero Valery Melnikov Elena Castro-Rodríguez Armando Gamboa-Domínguez Alejandrina Rodríguez-Hernández Mónica Lemus Jesús Muñiz Murguía

BACKGROUND Physical exercise improves glucose metabolism and insulin sensitivity. Brain-derived neurotrophic factor (BDNF) enhances insulin activity in diabetic rodents. Because physical exercise modifies BDNF production, this study aimed to investigate the effects of chronic exercise on plasma BDNF levels and the possible effects on insulin tolerance modification in healthy rats. METHODS Wis...

ژورنال: طب مکمل 2018

Introduction: This study aimed to investigate the effect of resistance and aerobic exercises with different intensities on BDNF & TrkB receptor gene expression in ovariectomized mice. Methods: Sixty 6 to 8-month old mice with average weight of 230 ±10 g were randomly divided into six 10-member groups: ovariectomized + high-intensity resistance exercises, ovariectomized + low-intensity resistan...

Journal: :The Journal of biological chemistry 1994
M Guiton F J Gunn-Moore T N Stitt G D Yancopoulos J M Tavaré

Brain-derived neurotrophic factor (BDNF) interacts with the TrkB receptor tyrosine kinase, the tyrosine kinase domain of which has homology with the insulin receptor subfamily of protein kinases. This includes the conservation of three regulatory tyrosines (residues 670, 674, and 675) known to play a crucial role in signal transmission by the insulin receptor (tyrosines 1158, 1162, and 1163). W...

ژورنال: دانشور پزشکی 2009
امینی, حسام , حشمتی, دکتر مرجان , دلشاد, دکتر علیرضا ,

  Background & Objective : As apoptotic cell death plays an important role in natural development and many pathologic conditions such as cancer and neurodegenerative diseases, understanding of its molecular mechanisms can be useful in designing new therapeutic strategies. In present study following induction of apoptosis in spinal motoneurons, expression of neurotrophic factor BDNF, and its rec...

Journal: :Bioscience trends 2017
Ting Cao Qiwei Guo Mi Su Yue Feng Mei Fan Yanjun Si Nazakat H Memon Jia Lin Dingzhi Fang

Tropomyosin-related kinase receptor B (TrkB) has been observed to be a common player in posttraumatic stress disorder (PTSD) and the regulation of serum lipids levels. However, interplays of PTSD with TrkB on serum lipids levels have not been explored yet. This study was to investigate the interplays of PTSD and TrkB rs1187327 on serum lipid profiles. Variants of TrkB rs1187327 of 709 high scho...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1996
C S von Bartheld R Williams F Lefcort D O Clary L F Reichardt M Bothwell

The receptors involved in retrograde transport of neurotrophins from the retina to the isthmo-optic nucleus (ION) of chick embryos were characterized using antibodies to the p75 neurotrophin receptor and trkB receptors. Survival of neurons in the ION has been shown previously to be regulated by target-derived trophic factors with survival promoted or inhibited by ocular injection of brain-deriv...

Journal: :Glycobiology 2007
Alicja Woronowicz Schammim Ray Amith Vanessa W Davis Preethi Jayanth Kristof De Vusser Wouter Laroy Roland Contreras Susan O Meakin Myron R Szewczuk

Trypanosome trans-sialidase (TS) is a sialic acid-transferring enzyme and a novel ligand of tyrosine kinase (TrkA) receptors but not of neurotrophin receptor p75NTR. Here, we show that TS targets TrkB receptors on TrkB-expressing pheochromocytoma PC12 cells and colocalizes with TrkB receptor internalization and phosphorylation (pTrkB). Wild-type TS but not the catalytically inactive mutant TSDe...

2015
Nitin Chitranshi Vivek Gupta Sanjay Kumar Stuart L. Graham Christo Z. Christov

7,8-dihydroxyflavone (7,8-DHF) is a TrkB receptor agonist, and treatment with this flavonoid derivative brings about an enhanced TrkB phosphorylation and promotes downstream cellular signalling. Flavonoids are also known to exert an inhibitory effect on the vascular endothelial growth factor receptor (VEGFR) family of tyrosine kinase receptors. VEGFR2 is one of the important receptors involved ...

2016
Ji-chun Zhang Wei Yao Kenji Hashimoto

Depression is the most prevalent and among the most debilitating of psychiatric disorders. The precise neurobiology of this illness is unknown. Several lines of evidence suggest that peripheral and central inflammation plays a role in depressive symptoms, and that anti-inflammatory drugs can improve depressive symptoms in patients with inflammation-related depression. Signaling via brain-derive...

Journal: :Folia neuropathologica 2006
Katarzyna Kotulska Magdalena Larysz-Brysz Wiesław Marcol Izabela Malinowska Iwona Matuszek Wiesława Grajkowska Joanna Lewin-Kowalik

Persisting motor function deficit after peripheral nerve injury often results from axotomized motoneuron death. Brain-derived neurotrophic factor (BDNF) and its receptor, trkB, are known to promote peripheral nerve regeneration. However, the requirement of BDNF and trkB for adult motoneuron survival after peripheral nerve injury is not established. We studied the number of surviving and regener...

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