نتایج جستجو برای: triptolide

تعداد نتایج: 676  

Journal: :Neuroscience letters 2010
Xinmiao Ren Ting Zhang Jing Hu Wei Ding Xiaomin Wang

Adeno-associated virus (AAV) mediated gene transfer has been demonstrated to be an effective approach for treating Parkinson's disease (PD). Triptolide T10 is a monomeric compound isolated from tripterygium wilfordii Hook.f. (Thunder God vine), a traditional Chinese herb for anti-inflammatory medications. In the present study, we co-administered T10 with recombinant AAV2 in SH-SY5Y human neurob...

2018
Zhenyan Hou Lei Chen Pingfei Fang Hualin Cai Huaibo Tang Yongbo Peng Yang Deng Lingjuan Cao Huande Li Bikui Zhang Miao Yan

Triptolide (TP), the main bioactive component of Tripterygium wilfordii Hook F, can cause severe hepatotoxicity. Isoliquiritigenin (ISL) has been reported to be able to protect against TP-induced liver injury, but the mechanisms are not fully elucidated. This study aims to explore the role of nuclear transcription factor E2-related factor 2 (Nrf2) and hepatic transporters in TP-induced hepatoto...

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