The ubiquitin-proteasome pathway plays a critical role in the intracellular trafficking of AAV2 vectors, and phosphorylation of certain surface-exposed amino acid residues on the capsid provides the primary signal for ubiquitination. Removal of several critical tyrosine (Y) and serine (S) residues on the AAV2 capsid has been shown to significantly increase transduction efficiency compared with ...

OBJECTIVE Helicobacter pylori (HP) is the world's most common infectious agent. Despite conventional therapy consisting of proton pump inhibitor (PPI), amoxicillin (AMO) and clarithromycin (CLA), approximately half of the patients remain infected. We compared the PPI-based triple therapy with quadruple treatment (BPMT) including bismuth citrate (BS), PPI, metronidazole (MET) and tetracycline (T...

aim : the aim of this study was to compare the half-dose and full-dose triple therapy regimens for helicobacter pylori ( hp ) eradication in patients with end-stage renal disease. background : h. pylori is one the most important causes of dyspepsia in patients with end-stage renal disease (esrd). patients and methods : sixty-six patients with esrd were enrolled in the study with hp infection an...

background : eradication of helicobacter pylori infection plays a crucial role in the treatment of peptic ulcer. clarithromycin resistance is a major cause of treatment failure. this randomized clinical trial aimed at evaluating the efficacy of a clarithromycin versus gemifloxacin containing quadruple therapy regimen in eradication of h. pylori infection. methods : in this randomized double bli...

The purpose of this article is to study how q-real numbers can be used for computations convergence regions, q-integral representations certain multiple triple q-Lauricella functions. corresponding q-difference equations are also given without proof. In the process, we slightly improve Exton’s original formulas. We survey current attempts generalize above functions and quadruple hypergeometric ...

PURPOSE Due to the low abundance of cone photoreceptors in the mouse retina and the scarcity of alternative animal models, little is known about mechanisms of cone degeneration. Nrl knockout mice develop exclusively the cone-type of photoreceptors. However, the cone photoreceptor layer in Nrl(-/-) mice displays an irregular morphology with severe rosette formation. Retinas of Rpe65(-/-);Nrl(-/-...