نتایج جستجو برای: trio
تعداد نتایج: 2043 فیلتر نتایج به سال:
The presence of genotyping errors can invalidate statistical tests for linkage and disease association, particularly for methods based on haplotype analysis. Becker et al. have recently proposed a simple likelihood ratio approach for detecting errors in trio genotype data. Under this approach, a SNP genotype is flagged as a potential error if the likelihood associated with the original trio gen...
Small Rho-GTPases are enzymes that are bound to GDP or GTP, which determines their inactive or active state, respectively. The exchange of GDP for GTP is catalyzed by so-called Rho-guanine nucleotide exchange factors (GEFs). Rho-GEFs are characterized by a Dbl-homology (DH) and adjacent Pleckstrin-homology (PH) domain that serves as enzymatic unit for the GDP/GTP exchange. Rho-GEFs show differe...
TRIO and F-actin-binding protein (TrioBP), which was initially discovered as a binding partner of Trio and F‑actin, is a critical factor associated with hearing loss in humans. However, the function of TrioBP in cancer has not been investigated. In the present study, TrioBP expression was indicated to be highly elevated in U87‑MG and U343‑MG cells. Furthermore, the TrioBP mRNA expression level ...
In population genotyping, it is common to genotype family trios consisting of the two parents and their child since that allows to recover haplotypes with higher confidence. Interestingly, the available software tools are primarily intended to phase only unrelated genotypes. In this section we first formulate the problem and describe specificity of family trio phasing and then analyze existing ...
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