INTRODUCTION We report the impact of canakinumab, a fully human anti-interleukin-1β monoclonal antibody, on inflammation and health-related quality of life (HRQoL) in patients with difficult-to-treat Gouty Arthritis. METHODS In this eight-week, single-blind, double-dummy, dose-ranging study, patients with acute Gouty Arthritis flares who were unresponsive or intolerant to--or had contraindica...

Subcutaneous calcification following injection of triamcinolone hexacetonide for plantar fasciitis SIR, We report a patient who developed subcutaneous calcinosis and ulceration over the heel following injection of triamcinolone hexacetonide. This agent has the potential to cause complications many years after treatment. A 67-yr-old lady was referred with a weeping ulcer on the medial aspect of ...

background : seroma formation is a common problem following axillary dissection. it is probably caused by a local inflammatory response. local steroids may prevent this problem by inhibiting inflammatory response at the wound site. methods : this randomized prospective study was undertaken to evaluate the effect of local triamcinolone injection on seroma formation following axillary dissection....

OBJECTIVE The aim of this study was to evaluate the response of treatment of central giant cell lesion to intralesional corticosteroid injections. STUDY DESIGN Review of articles indexed in PubMed on the topic between the years 1988 and 2011, and development of a descriptive meta-analysis of the results. RESULTS Sample of 41 patients primarily treated with intralesional corticosteroid injec...

OBJECTIVE To evaluate the efficacy and safety of 1-mg and 4-mg doses of preservative-free intravitreal triamcinolone in comparison with focal/grid photocoagulation for the treatment of diabetic macular edema (DME). DESIGN Multicenter, randomized clinical trial. PARTICIPANTS Eight hundred forty study eyes of 693 subjects with DME involving the fovea and with visual acuity of 20/40 to 20/320....

Hydrochloric acid and/or sodium hydroxide may be used during manufacture to adjust pH of suspension to approximately 6. Triamcinolone diacetate is practically insoluble in water; soluble in chloroform; sparingly soluble in alcohol and in methanol; and slightly soluble in ether. This preparation is suitable for parenteral administration through a 23-gauge needle (or larger), but NOT suitable for...

Subclinical inflammation occurring in diabetic retinopathy is supposed to be, at least partly, the cause of breakage of blood-retinal barrier. It may be expected that anti-inflammatory drugs have favorable effect on the course of diabetic macular oedema. The aim was to investigate the effect of intravitreally applied triamcinolone acetonide (TA) on resolution of diffuse diabetic macular oedema ...

Choroidal neovascularization (CNV) secondary to age related macular degeneration is among the leading causes of legal blindness in developed countries. Photodynamic therapy (PDT) with verteporfin induces CNV closure causing little damage to healthy tissue, but the need to re-treat may lead to low final visual acuity at an unacceptable cost. The association of intravitreous triamcinolone or anti...

We present a case of diabetic macular edema in a pregnant patient treated with a single intravitreal injection of triamcinolone acetonomide. Initial presentation and serial examinations after treatment included visual acuity, slit-lamp examination, indirect ophthalmoscopy, and optical coherence tomography. Resolution of visual acuity and macular edema were present six weeks after injection and ...