BACKGROUND Nociceptive and neuropathic pain occurs as part of the disease process after traumatic brain injury (TBI) in humans. Central and peripheral inflammation, a major secondary injury process initiated by the traumatic brain injury event, has been implicated in the potentiation of peripheral nociceptive pain. We hypothesized that the inflammatory response to diffuse traumatic brain injury...

two dogs with generalized seizures were evaluated. the dogs were diagnosed with traumatic intracranial hemorrhages based on the history, neurological examinations, and magnetic resonance imaging (mri) of the brain. treatment was started with oxygen, prednisolone and anticonvulsant agents. no further seizure activity was observed after treatment in both dogs, however cushing reflex was detected ...

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purpose: blast-induced traumatic brain injury (btbi) is one of the causes of death or permanent   invalidity which can occur unexpectedly in both military and civilian populations. this study   set out to conduct a combined eulerian-lagrangian computational analysis of the interaction   between a single planar blast wave and a human head in order to assess the extent of intracranial   shock wav...

Traumatic brain injury is a serious global health problem with irreversible high morbidity and disability and Because of its unknown pathophysiological mechanisms, efficient therapeutic approaches to improve the poor outcome and long-term impairment of behavioral function are still remains lacking. The microglial cells are the resident macrophage cells of the brain and have M1/M2 phenotype, for...

Traumatic brain injury is the leading killer after trauma, in part because of coagulopathy. Factor VIIa may be a useful therapy in this setting, depending on the relative risk for thromboembolic complications. Kluger and coworkers recently conducted a retrospective review of patients with traumatic brain injury from a previous factor VIIa and trauma trial. It documents an encouragingly low rate...

Spinal cord injury (SCI) is often complicated by secondary ischemic injury as a result of the innate inflammatory response to traumatic injury and tissue swelling. Prior studies have shown that excessive ATP release from peri-traumatic regions contributes to the inflammatory response to SCI by activation of low affinity P2X7 receptors. Since connexin hemichannels constitute an important route f...

BACKGROUND Little empiric research has investigated the interrelationship between homelessness and traumatic brain injury. The objectives of this study were to determine the rate, mechanisms and associated outcomes of traumatic brain injury among men in an urban homeless shelter. METHODS We recruited participants from an urban men's shelter in Toronto, Ontario. Researchers administered the Br...

OBJECTIVE Head injury is a leading cause of death and disability in subjects who suffer a traumatic accident. Contralateral hematomas after surgery for traumatic brain injury are rare. However, an unrecognized, these hematomas can cause devastating results. We presented our experience of these patients and discussed diagnosis and management. METHODS This study included 12 traumatic patients w...