Aim: To formulate and evaluate of transdermal patches ciprofloxacin hydrochloride. Materials Methods: maximise bioavailability by avoiding pre-systemic hepatic metabolism, an effort was made to design a treatment system for Ciprofloxacin hydrochloride employing polymers such as HPMC, EC, ERS100. Physical chemical characteristics, in vitro drug release investigations stability experiments were c...

BACKGROUND Nitrates are widely used in the treatment of angina in patients with acute myocardial infarction (AMI). Short-term administration prevents left ventricular (LV) dilation and infarct expansion. However, little information is available regarding their long-term effects on LV remodeling in patients surviving Q-wave AMI. METHODS AND RESULTS This was a randomized, double-blind, placebo-...

The purpose of the study was to develop a transdermal tolterodine tartrate (TT) patch and to analyse its efficacy for overactive bladder (OAB) treatment. Patches were prepared using various polymers and plasticizers via the solvent casting method. The patches were characterized for tensile strength, thickness, moisture content, modulus of elasticity and water absorption capacity. Differential s...

Ovarian cancer is the fifth most commonly occurring malignancy in women, with the highest mortality rate among all the gynecological tumors. Microparticulate vaccine can serve as an immunotherapeutic approach with a promising antigenic delivery system without a need for conventional adjuvants. In this study, a microparticulate vaccine using whole cell lysate of a murine ovarian cancer cell line...

INTRODUCTION: The age-old theory that imparted the status of “dead, impermeable barrier devoid of biological activity” to skin had already been challenged by the development of pioneering transdermal product, but a less than impressive commercial growth in this sector had raised some doubts about the feasibility of this route as an efficient device of drug delivery. The journey of transdermal r...

BACKGROUND Nitrates are widely used to treat coronary artery disease, but their therapeutic value is compromised by the rapid development of tolerance. Recently, the renin-angiotensin system has been suggested to play an important role in the development of nitrate tolerance. METHODS AND RESULTS Sixty-four patients with coronary spastic angina were investigated to clarify the effect of angiot...

To date, transdermal delivery has been effective in delivering only a very few drugs due to diffi culties in moving larger, and chemically non-compatible, molecules across the skin’s biologically-active barrier. Drugs with higher melting points, drugs of molecular weight greater than 500 Daltons and drugs requiring pharmacological doses of more than 40 mg in 24 hours can not employ patchor gel-...

Drug delivery by means of transdermal patches raised great interest as a non-invasive and sustained therapy. The present research aimed to design a patch for transdermal delivery of melatonin, which was encapsulated in polycaprolactone (PCL) nanoparticles (NPs) by employing flash nanoprecipitation (FNP) technique. Melatonin-loaded PCL nanoparticles were successfully prepared with precise contro...