Development of controlled release transdermal dosage form is a complex process involving extensive research. Transdermal patches have been developed to improve clinical efficacy of the drug and to enhance patient compliance by delivering smaller amount of drug at a predetermined rate. This makes evaluation studies even more important in order to ensure their desired performance and reproducibil...

Transdermal Drug Delivery In article 2300066, Canan Dagdeviren and co-workers report a soft, conformable embodiment of wearable ultrasound patch for transdermal delivery cosmeceuticals to the skin. The comprises 2D array bulk piezoelectric transducers embedded in poly(dimethylsiloxane) substrate. demonstrates 26.2-fold enhancement niacinamide porcine skin vitro with 10 min application.

AIM The aim of this study was to determine and compare the effect of treatment with transdermal oestrogen and phytoestrogen on insulin sensitivity and sex hormone-binding globulin (SHBG) levels in healthy postmenopausal women. METHODS Forty-three healthy postmenopausal women aged 68 ± 7 (mean ± SD) years who were not receiving hormonal replacement therapy completed a 3 month randomized drug t...

Article history: Received on: 07/11/2013 Revised on: 21/12/2013 Accepted on: 16/01/2014 Available online: 27/02/2014 Nisoldipine is used for treatment of hypertension and angina pectoris. However, it suffers from very low bioavailability due to its extensive pre-systemic metabolism. This together with its low dose made it excellent candidate for transdermal delivery. Accordingly, the aim of thi...

Opioids continue to be first-line pharmacotherapy for patients suffering from cancer pain. Unfortunately, subtherapeutic dosage prescribing of pain medications remains common, and many cancer patients continue to suffer and experience diminished quality of life. A large variety of therapeutic options are available for cancer pain patients. Analgesic pharmacotherapy is based on the patient's sel...

background: due to its minimal systematic adverse effects, transdermal estrogen is widely used for the prevention of osteoporosis in postmenopausal women.the present meta-analysis aimed to clarify the effects of transdermal estrogen on bone mineral density (bmd) of postmenopausal women.methods: studies were identified by searching electronic databases including cochrane library, medline, embase...

the present study was performed to explore the matrix property of ficus glomerata fruit mucilage for making transdermal patches. the mucilage was evaluated for its physicochemical properties. various transdermal patches of indomethacin were prepared by solvent evaporation technique using different proportions of f. glomerata fruit mucilage. the compatibility studies between indomethacin and f. ...