background and objectives: silymarin is a unique flavonoid complex with documented hepatoprotective properties. silybum  marianum hairy root culture as a source for producing silymarin has been an important strategy for study the cell signaling pathway. in the present investigation trichoderma strains- silybum marianum hairy root cultures interactions have been studied. methods: the effects of ...

metabolic syndrome (mets) is characterized by a cluster of cardiovascular risk factors that include: abdominal obesity, dyslipidaemia, hypertension, insulin resistance and impaired glucose tolerance. recent genome wide association studies have identified several susceptibility regions involved in lipid metabolism that are also associated with mets. we have explored the association of 9 genetic ...

infection with human immunodeficiency virus (hiv) is a progressive condition which may cause endothelial dysfunction and liver damage leading to coagulopathy. with adventure of highly active antiretroviral therapy (haart), life expectancy has prolonged in hiv positive patients but several acquired immunodeficiency syndrome (aids)-related conditions such as coagulopathies are responsible for ass...

Introduction: Cardiomyocytes apoptosis contributes to the development of left ventricular hypertrophy. The Bcl-2 family members are important regulators of mitochondrial pathway of apoptosis. Monoterpenoid phenol –carvacrol– possesses strong antioxidant properties. The present study aimed to evaluate the effect of carvacrol on transcription level of pro-apoptotic (Bad and Bax) and...

Nitrogen catabolite repression (NCR)-sensitive genes, whose expression is highly repressed when provided with excess nitrogen and derepressed when nitrogen is limited or cells are treated with rapamycin, are routinely used as reporters in mechanistic studies of the Tor signal transduction pathway in Saccharomyces cerevisiae. Two GATA factors, Gln3 and Gat1, are responsible for NCR-sensitive tra...

The transcription factor E2F-1 drives proliferation and death, but the mechanisms that differentially regulate these divergent actions are poorly understood. The hypoxia-inducible death factor Bnip3 is an E2F-1 target gene and integral component of the intrinsic mitochondrial death pathway. The mechanisms that govern Bnip3 gene activity remain cryptic. Herein we show that the transcription fact...

Objective Thyroid cancer (TC) is one of the fastest-growing malignant tumors. This study sought to explore mechanism immune escape mediated by receptor tyrosine kinase (KIT) in TC. Methods The expression microarray TC was acquired through GEO database, and difference analysis Kyoto encyclopedia genes genomes pathway enrichment were carried out. KIT levels cell lines (K1/SW579/BCPAP) human norma...

Abstract YAP1 is a transcriptional co-activator and oncogene under the control of Hippo Signaling Pathway. Functional inactivation Pathway tumor suppressors, including NF2, are frequent events in human cancers. Meningiomas most common primary brain tumors, large percentage exhibit heterozygous loss chromosome 22 (harboring NF2 gene) functional remaining gene copy, implicating oncogenic YAP acti...

Induction of new hair follicles (HFs) may be an ultimate treatment goal for alopecia; however, functional cells with HF inductivity must expanded in bulk clinical use. In vitro culture conditions are completely different from the vivo microenvironment. Although fetal and postnatal dermal (DCs) have potential to induce HFs, they rapidly lose this during culture, accompanied by a drastic change g...