Transcranial magnetic resonance (MR)-guided high-intensity focused ultrasound (tcMRgHIFU) implies a novel, noninvasive treatment strategy for various brain diseases. Nine patients with chronic neuropathic pain were treated with selective medial thalamotomies. Precisely located thermal ablations of 4mm in diameter were produced at peak temperatures of 51 degrees C to 60 degrees C under continuou...

BACKGROUND The aetiology of central nervous system lesions observed in cerebral cyclosporine neurotoxicity remains controversial. CASE PRESENTATION We report a 48-year-old woman with a non-severe aplastic anaemia who presented with stroke-like episodes while on cyclosporine treatment.Transcranial Doppler ultrasound revealed severely elevated flow velocities in several cerebral vessels, consis...

Transcranial Doppler ultrasound allows measurements of blood flow velocity to be made from the basal intracerebral vessels. The major advantages of transcranial Doppler ultrasound are that it is non-invasive, relatively cheap, can be performed with portable machines, allows monitoring for prolonged periods, and has a high temporal resolution making it ideal for studying dynamic cerebrovascular ...

The speckle in ultrasound images has long been thought to contain information related to the tissue microstructure. Many different investigators have analyzed the frequency characteristics of the backscattered signals to estimate the scatterer acoustic concentration and size. Previous work has been mostly restricted to unfocused or weakly focused ultrasound sources, thus limiting its implementa...

PURPOSE To study the phase aberrations produced by human skulls during transcranial magnetic resonance imaging guided focused ultrasound surgery (MRgFUS), to demonstrate the potential of Zernike polynomials (ZPs) to accelerate the adaptive focusing process, and to investigate the benefits of using phase corrections obtained in previous studies to provide the initial guess for correction of a ne...

The present study aimed to investigate the clinical efficacy of transcranial ultrasound as an adjuvant therapy in combination with small doses of urokinase (UK) for the treatment of progressive cerebral infarction. Sixty-one eligible patients with progressive cerebral infarction were successively and randomly assigned into one of the following groups; 30 patients to the treatment group (transcr...