Amiodarone is a drug which frequently causes elevated transaminases. However, acute liver failure has been rarely reported. Here, we present a case of fatal acute liver failure following the administration of intravenous amiodarone. It is important to be aware of this rare but potentially fatal complication of intravenous amiodarone so that it can be withdrawn immediately at the first sign of h...

BACKGROUND The Institute of Medicine (IOM) reports that at least a fourth of all medication related injuries are preventable. Therefore, the IOM recommends healthcare organizations and providers implement electronic prescribing and clinical decision support systems in practices to aid in medication error prevention. OBJECTIVE To assess the impact of noninstrusive-intrusive prompts from an ele...

In August 2009, a 28-year-old Spanish woman was referred in reduced general condition after at least four medical consultations with a 2 week history of remittent fever, night sweats, exanthema and intermittent arthralgias. Noticeable in the clinical examination was only an urticarial rash on the trunk and extremities and body temperature of 39.6°C. Laboratory tests: WBC with a slight left shif...

In vitro supplementation with the active form of vitamin B6, pyridoxal-phosphate (PLP), increases measurements of both serum aminotransferase enzymes, L-aspartate: 2-oxoglutarate amino transferase, EC 2.6.1.1 (AST) and L-alanine: 2-oxoglutarate aminotransferase, EC 2.6.1.2 (ALT). The plasma PLP level in normal individuals clearly relates inversely to the degree of stimulation of serum AST and A...

Modern tools for enzyme discovery andprotein engineering substantially broadened thenumber of enzymes applicable for biocatalysis andhelped to alter their properties such as substraterange, enantioselectivity, and stability under processconditions. In addition, these methods also enabledone to explore reactions for organic synthesis forwhich no suitable enzymes were ...

OBJECTIVE: Routine testing of hepatic transaminases, amylase, and lipase has been recommended for all children evaluated for physical abuse, but rates of screening are widely variable, even among abuse specialists, and data for amylase and lipase testing are lacking. A previous study of screening in centers that endorsed routine transaminase screening suggested that using a transaminase thresho...

were anicteric leptospirosis.1 Main presentation in our cases was Weil’s disease, so, it is difficult to draw conclusions from only two patients of anicteric leptospirosis. As far as the study of Elizabeth F Daher et al is concerned this study also had Jaundice in 94.5% patients out of total 201 patients.2 MAT is a highly specific test, though sensitivity is poor, whereas mildly raised transami...

Sir, Paracetamol poisoning is not a very frequently encountered problem in ouur population, as compared to the incidence in the west. Paracetamol (acetaminophen) is being used as an effective and safer analgesic as compared to non-steroidal anti inflammatory drugs, when administered in therapeutic dose. In contrast to aspirin, it is more likely to cause hepatotoxicity, when taken in larger than...