Background: Naturally extracted trans-(−)-kusunokinin from P. nigrum showed anticancer activities via binding and inhibition of CSF1R. However, the synthetic racemic mixtures trans-(−)- trans-(+)-kusunokinin (trans-(±)-kusunokinin) exhibited different effects on breast cancer cell lines. It was hypothesized that trans-(±)-kusunokinin bind to additional molecules, including AKR1B1. Previously, w...

Density Functional Theory (DFT) calculations have been performed on the TTC-->TTT isomerization reaction of the open forms of the 1',3'-dihydro-8-bromo-6-nitro-1',3',3'-trimethylspiro[2H-1-benzopyran-2,2'-(2H)indole (8-Br-6-nitro-BIPS) system. The calculations were carried out in vacuo and in methylene chloride solution at different temperatures. Results are compared with the available experime...

In this commentary, we endorse concerns about the health impact of the trans-pacific partnership (TPP), paying particular attention to its mechanisms for investor state dispute settlement. We then describe the different, judgeled approach being advocated by the European Commission team negotiating the Trans-Atlantic Trade and Investment Partnership, arguing that, while not perfect, it offers si...

background :  q fever is an important widespread reemerging zoonosis. the presence of coxiella burnetii in 100 tick-infested dogs was assessed in this study. methods :  the blood samples from 100 referred dogs were acquired and evaluated by nested-pcr. results :   c. burnetii was detected in 11 out of 100 (11%) blood samples. most of the positive dogs were kept outdoor and fed on raw diet. base...

backgroundbody image is a determinant of individual attractiveness and physical activity among the young people. this study was aimed to assess the association of trans-theoretical model based exercise behavior change with body image evaluation among the female iranian students.materials and methodsthis cross-sectional study was conducted in sanandaj city, iran in 2016. using multistage samplin...

the aim of this study is to investigate and determine the best aja’s information confrontation methods and techniques against the extra-regional forces. according researches in various sources can be realized, trans-regional forces approaches in the world of modern communications, brought under control the international community as a village and many of the information in the fields communicat...

the volatile constituents of aerial parts of euphorbia aellenii rech.f. and e. microsciadea boiss. were analyzed by gas chromatography (gc) and gc-mass spectrometry (ms) methods. the main volatile constituents of e. aellenii were phytol isomer (47.3%), camphene (31.9%) and caryophyllene oxide (20.6%), while the major volatile components of e. microsciadea were trans-anethole (74.5%), limonene (...

The synthesis and characterization of the isomeric ruthenium complexes with general formula cis- trans-[Ru(trpy)(qc)X]n+ (trpy is 2,2':6',2?-terpyridine, qc 8-quinolinecarboxylate, cis-1 trans-1, X = Cl, n 0; cis-2 trans-2, X=OH2, 1) respect to relative disposition carboxylate ligands are reported. For comparison purposes, another set trans-[Ru(trpy)(pic)(OH2)]+ (pic 2-picolinate (cis-3, trans-...

“Trans” offers Victorian studies two different but ultimately intertwined methods for studying sex and gender in a historically bounded discipline: nominal, biographical work theoretical, conceptual work. While accounts tend to evoke historicist concerns of anachronism, the theoretical potential “trans” is largely untouched studies. This Keywords essay argues that such much needed analyses gend...

[1] R. B. Assunção, P. C. Carrião, O. H. Miyagaki, Multiplicity of solutions for critical singular problems, Applied Mathematics Letters 19 (2006) 741–746. [2] R. B. Assunção, P. C. Carrião, O. H. Miyagaki, Critical singular problems via concentration-compactness lemma, J. Math. Anal. Appl. 326 (2007), 137–154. [3] J. Chen, S. Li, On multiple solutions of a singular quasilinear equation on unbo...