The management of chronic disseminated intravascular coagulation (DIC) caused by aortic dissection has not yet been established. Even in cases where surgical correction is performed, therapeutic control of systemic hemorrhaging is still required. We herein report the successful treatment of a case of aortic dissection with a patent false lumen using tranexamic acid for acute exacerbation of chr...

Introduction: Hysterectomy is one of the frequently performed major gynecological surgicalprocedures for various uterine pathologies. The objective this study to assess effect ofintravenous tranexamic acid in reducing intraoperative and postoperative blood loss womenundergoing abdominal hysterectomy. Materials Methods: was a randomizeddouble-blind study, involving total 120 women undergoing hys...

The withdrawal of marketing approval for aprotinin resulted in more clinicians administering tranexamic acid to patients at increased risk of bleeding and adverse outcome. The latest in a series of retrospective analyses of observational data is published in Critical Care and suggests an increase in mortality, when compared to data from the aprotinin era, in those patients having surgery when a...

The CRASH 2, a randomized, double-blind, controlled trial, that enrolled 20,211 adult trauma patients, has shown that the administration of tranexamic acid significantly reduces all-cause mortality and that specifically associated with severe blood loss as well. We consider it a significant therapeutic advance, because, for the first time, a drug has been demonstrated to safely diminish mortali...

TBE-CiTE Journal Club: January 17, 2012, with the participation of the following institutions: Trauma Research Program of the Department of Surgery of the Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada; Division of Trauma Surgery, University of Campinas, Campinas, Brazil. 1.Fellow, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada; 2. Professor...

T rauma is a major cause of death world wide. The major cause of trauma-related death is hemorrhage which can also contribute to multiorgan failure-associated death. It is known that antifibrinolytic agents reduce perioperative blood loss and the need of transfusion (1). Because the haemostatic responses to sur gery and trauma seem to be similar, it was su pposed that tranexamic agent, an antif...