TLR4 is unique among pathogen-recognition receptors in that it initiates different pathways in different cellular locations. Binding of a bridging factor, Mal, allows recruitment of an adapter protein, MyD88, at the plasma membrane, which leads to the production of proinflammatory cytokines. Upon internalization, TLR4 uses a different bridging factor, TRAM, to activate a MyD88-independent pathw...

In pyramidal neurons such as hippocampal area CA1 and basolateral amygdala, a slow afterhyperpolarization (sAHP) follows a burst of action potentials, which is a powerful regulator of neuronal excitability. The sAHP amplitude increases with aging and may underlie age related memory decline. The sAHP is due to a Ca(2+)-dependent, voltage-independent K(+) conductance, the molecular identity of wh...

T. M. Cover, “Broadcast channels,” IEEE Tram. Inform. Themy, vol. IT-IS, pp. 2-14, Jan. 1972. P. P. Bergmans, “Random coding theorem for broadcast channels with degraded components,” IEEE Tram. Inform. Theory, vol. IT-19, pp. 197-207, Mar. 1973. E. C. Van Der Meulen, “Random coding theorems for the general discrete memoryless broadcast channel,” IEEE Trans. Inform. Theory, vol. IT-21, pp. 180-1...

This paper is produced and circulated privately and its inclusion in the conference does not constitute publication. Abstract The UK currently only has one new light rail (tram) scheme being implemented. By way of contrast, a number of high-quality bus systems have been developed; for example Cambridge and Luton Guided-busways, Thames Gateway Fastrack, Crawley Fastway and 'streetcar' bus operat...

The magnetic geared permanent magnet synchronous motor (MG-PMSM) is a PMSM that has two rotors with different rotation speeds and includes the function of gear. design studies 45kW-class MG-PMSM are conducted for application driving system tram. In this research, first, to derive detailed model tram, analysis characteristics according stator winding method was performed. After selecting can red...

Background: Although many studies have identified the key factors influencing travel mode, they typically centred around survey data, which has several limitations. In this research, actual transport data (GPS) been provided by Google Environment Insights Explorer (EIE) for 169 municipalities in Australia across 2018 and 2019. Objective: A outcome of paper is to project independent impact new p...

Tien Manh Huynh, Quang Dinh Le, Mai Ngoc Luu, Tram Thi Huyen Nguyen, Quy Nhuan Bui, Anh Phan Tuong Mai, Thang Hiep Duc Tran, Hien Minh Cong Hong Vo, and Trong Quach. Int J Gastrointest Interv 2022;11:135-8. https://doi.org/10.18528/ijgii220007

A trans-farnesyl pyrophosphate-squalene synthetase has been isolated in a soluble form from yeast extracts and purified 45fold. The molecular weight of the enzyme estimated from sucrose density gradient centrifugation and gel filtration chromatography is 426,000. Solubilization of the squalene synthetase is achieved with deoxycholate. Treatment with the detergent markedly lowers squalene synthe...