OBJECTIVE This study was performed to investigate bone deteriorations and calcium homeostasis of GIOP mice in response to the treatment of icariin. METHODS The biomarkers in serum and urine were measured, tibias were taken for the measurement on bone calcium, gene expression, histomorphology and micro-CT. RESULTS Glucocorticoid-treated facilitated to induce hypocalcemia and hypercalciuria i...

Trabecular morphology has structural trends which are strongly correlated with physical function. In vivo analysis of the trabecular pattern has the potential to predict and treat malgrowth of bone owing to altered loading conditions in an early phase. Using multiscale texture analysis we determine the orientation trend of the trabecular network from CT images. First studies show that the obtai...

Introduction: Subchondral bone defects in the proximal tibia are commonly encountered with tibial plateau fractures. Bone defects and grafting treatments affect knee mechanics but the effects are not well understood. Changes in subchondral strain affect cartilage stress which likely contributes to posttraumatic arthritis. Historically, investigators have had to use analytical models to study tr...

1. The mean attenuation coefficients of trabecular and cortical bone in the radius were measured in 32 female patients with fractured proximal femur, and in 28 age-matched female controls, with a special-purpose computed tomography-scanner. 2. The largest difference between the two groups was in the mean attenuation coefficients for trabecular bone in the distal radius. The mean value for fract...

INTRODUCTION The objective of this study was to assess three-dimensional bone geometry and density at the epiphysis and shaft of the third meta-carpal bone of rheumatoid arthritis (RA) patients in comparison to healthy controls with the novel method of peripheral quantitative computed tomography (pQCT). METHODS PQCT scans were performed in 50 female RA patients and 100 healthy female controls...

Microdamage is an important component of bone quality and affects bone remodeling. Improved techniques to assess microdamage without the need for histological sectioning would provide insight into the role of microdamage in trabecular bone strength by allowing the spatial distribution of damage within the trabecular microstructure to be measured. Nineteen cylindrical trabecular bone specimens w...

INTRODUCTION: Fragility fracture is a serious and costly public health issue [1] and improved methods for screening, diagnosis and treatment monitoring of metabolic bone disease are needed. In particular, there is strong interest in non-invasive, clinically applicable MRI methods to study trabecular bone structure in vivo [2, 3]. We employed a novel method, DDIF (Decay due to Diffusion in the I...

BACKGROUND Polymethyl methacrylate (PMMA) bone cement is widely used for osteoplasty. However, previous studies have demonstrated the adverse effects of PMMA due to its excessive stiffness and heat production. Recently, calcium phosphate cement (CPC) that overcomes those negative effects has been successfully applied in osteoplasty. The potential problem of CPC is markedly less initial stiffnes...

BACKGROUND Both gastrectomy (GX) and ovariectomy (OVX) induce osteopenia in man and experimental animals. The present study addresses the question--can alendronate, estrogen or parathyroid hormone (PTH) be used to treat established GX- or OVX -evoked osteopenia? METHODS Rats were GX-, OVX- or SHAM-operated 8 weeks before starting the treatment with drugs. Each group was then treated for 8 wee...

To establish whether the combination of anti-resorptive therapy with mechanical loading has a negative, additive or synergistic effect on bone structure, we assessed the separate and combined effects of risedronate and non-invasive dynamic loading on trabecular and cortical bone. Seventeen-week-old female C57BL/6 mice were given daily subcutaneous injections of vehicle (n=20) or risedronate at ...