Skeletal muscle is known to be a target for the active metabolite of thyroid hormone, i.e., 3,5,3'-triiodothyronine (T(3)). T(3) acts by repressing or activating genes coding for different myosin heavy chain (MHC) isoforms via T(3) receptors (TRs). The diverse function of T(3) is presumed to be mediated by TR-alpha(1) and TR-beta, but the function of specific TRs in regulating MHC isoform expre...

Kocaeli University, Arslanbey Agricultural Vocational School, TR-41285 Kartepe, Kocaeli, Turkey. TUBITAK, Research Institute for Genetic Engineering and Biotechnology, TR-41470 Gebze, Kocaeli, Turkey. Institute for Genetic Engineering and Biotechnology, Gajev trg 4/1 BH-71000 Sarajevo, Bosnia and Herzegovnia. Istanbul University, Molecular Biology and Genetics Department, TR-34118 Vezneciler, I...

The regurgitant volume of TR might increase dynamically despite unchanged effective regurgitant orifice area, thus exaggerating TR severity on echocardiographic assessment. Meanwhile, functional TR from various chronic and acute cardiomyopathies may significantly reverse either by itself or after medical treatment. Thus, integrated analysis on both cardiac imaging and clinical data of functiona...

The high peak-to-average power ratio (PAR) of the transmit signal is considered to be one major drawback of orthogonal frequency-division multiplexing (OFDM) systems. This paper analyzes the tone reservation (TR) technique for PAR reduction. It is shown that the good performance of TR is paid with an increase in average transmit power. Therefore, an extension of the TR scheme is considered, whi...

Let A and B be n n positive semidefinite Hermitian matrices, let c and/ be real numbers, let o denote the Hadamard product of matrices, and let Ak denote any k )< k principal submatrix of A. The following trace and eigenvalue inequalities are shown: tr(AoB) <_tr(AoBa), c_<0or_> 1, tr(AoB)a_>tr(AaoBa), 0_a_ 1, A1/a(A o Ba) <_ Al/(Az o B), a <_ /,a O, Al/a[(Aa)k] <_ A1/[(A)k], a <_/,a/ 0. The equ...

OBJECTIVES The goal of this study was to examine mortality associated with tricuspid regurgitation (TR) after controlling for left ventricular ejection fraction (LVEF), right ventricular (RV) dilation and dysfunction, and pulmonary artery systolic pressure (PASP). BACKGROUND Tricuspid regurgitation is a frequent echocardiographic finding; however, the association with prognosis is unclear. ...

Few treatments for obesity exist and, whereas efficacious therapeutics for hyperlipidemia are available, further improvements are desirable. Thyroid hormone receptors (TRs) regulate both body weight and cholesterol levels. However, thyroid hormones also have deleterious effects, particularly on the heart. The TR beta subtype is involved in cholesterol lowering and possibly elevating metabolic r...

BACKGROUND Given the common concomitance of tricuspid regurgitation (TR) with significant mitral stenosis, we aimed at exploring the relation between TR severity and pulmonary artery hypertension (PAH) in patients who underwent mitral balloon valvotomy (MBV). METHODS We analyzed the echocardiography data of 133 consecutive patients (82.0% female, mean age 44.68 ± 12.56 years) with different d...

We evaluated pharmacokinetics (PK) and pharmacodynamics (PD) induced by new formulations of tramadol (TR) in thermoreversible gels. The poloxamer- (PL-) tramadol systems were prepared by direct dispersion of the drug in solutions with PL 407 and PL 188. The evaluated formulations were as follows: F1: TR 2% in aqueous solution and F2: PL 407 (20%) + PL 188 (10%) + TR 2%; F3: PL 407 (25%) + PL 18...