Nigella sativa has been used as traditional medicine for centuries. The crude oil and thymoquinone (TQ) extracted from its seeds and oil are effective against many diseases like cancer, cardiovascular complications, diabetes, asthma, kidney disease etc. It is effective against cancer in blood system, lung, kidney, liver, prostate, breast, cervix, skin with much safety. The molecular mechanisms ...

In this note we show that the system of equations tx + ty = tp, ty + tz = tq , tx + tz = tr , where tx = x(x + 1)/2 is a triangular number, has infinitely many solutions in integers. Moreover we show that this system has rational three-parametric solution. Using this result we show that the system tx + ty = tp, ty + tz = tq , tx + tz = tr , tx + ty + tz = ts has infinitely many rational two-par...

The standard approach to classical dynamics is to form a Lagrangian which is a function of n generalized coordinates qi, n generalized velocities q̇i and parameter τ . The 2n variables qi, q̇i form the tangent bundle TQ. The passage from TQ to the cotangent bundle T ∗Q is achieved by introducing generalized momenta and a Hamiltonian. However, this procedure requires that the rank of Hessian matrix

Oral cancer is one of the most commonly known worldwide. Thymoquinone (TQ) an extract from Nigella sativa, has clinically been proven as anticancer therapeutic agent for oral due to its intrinsic pharmacological characteristics. Understanding mechanisms proliferation and death in presence TQ crucial so that insight interaction cells can be discovered. Cancer subjected uncontrolled factors envir...

The DNA damage-responsive protein kinases ATM and ATR phosphorylate SQ/TQ motifs that lie in clusters in most of their in vivo targets. Budding yeast Esc4p contains a cluster of SQ/TQ motifs, suggesting that it might be a target of Mec1p/Tel1p (yeast ATR/ATM). Here it is reported that Esc4p is phosphorylated by Mec1p in response to DNA damage during DNA replication and that cells lacking Esc4p ...

Let p be a prime and let q be a power of p. In this paper, by using generalized Reed-Solomon (GRS for short) codes and extended GRS codes, we construct two new classes of quantum maximum-distanceseparable (MDS) codes with parameters [[tq, tq − 2d+ 2, d]]q for any 1 ≤ t ≤ q, 2 ≤ d ≤ ⌊ tq+q−1 q+1 ⌋+ 1, and [[t(q + 1) + 2, t(q + 1)− 2d+ 4, d]]q for any 1 ≤ t ≤ q− 1, 2 ≤ d ≤ t+2 with (p, t, d) 6= (...

Cancer is one of the main causes of mortality in the world which appears by the effect of enviromental physico-chemical mutagen and carcinogen agents. The identification of new cytotoxic drugs with low side effects on immune system has developed as important area in new studies of immunopharmacology. Thymoquinone (TQ), derived from the medicinal spice Nigella sativa (also called black cumin) ex...

Recently, it was suggested the potential role of gamma-tocopheryl quinone (gamma-TQ), an oxidative metabolite of gamma-tocopherol, as a powerful chemotherapeutic agent, since it was shown that this molecule exerts powerful cytotoxic effects, induces apoptosis and escapes drug resistance in human acute lymphoblastic leukemia and promyelocytic leukemia cells. We have studied the apoptogenic poten...

Thymoquinone has been reported to exhibit antioxidant and anti-inflammatory effects. Inflammation plays an important role in pathogenesis of diabetic peripheral neuropathy. This study investigated the effects of TQ on proliferation and apoptosis of Schwann cells exposed to high glucose conditions and electrophysiological and morphological changes of the sciatic nerve in a DPN rat model as well ...

This descriptive study investigates in a rabbit model of atherosclerosis (i) the extent of atherogenesis induced by cyclosporine A (CsA) or hyperlipidemia alone or in combination and (ii) whether thymoquinone (TQ), a known herbal antioxidant, offers protection against these effects. New Zealand White female rabbits were assigned to five groups of six animals each: Group I, control; Group II, Cs...