sources, it is important that relevant models of human liver toxicosis are used in order to identify agents with therapeutic potential. Thus, we considered the use of hepatotoxic agents relevant to human liver toxicosis in assay protocols. Examples of such hepatotoxic agents include pharmaceutical agents like tacrine and nitrofurantoin. Tacrine (1,2,3,4tetrahydro-9-aminoacridine hydrochloride) ...

Our goal in this study was to compare magnetic resonance images and volumes of brain structures obtained alive versus postmortem of California sea lions Zalophus californianus exhibiting clinical signs of domoic acid (DA) toxicosis and those exhibiting normal behavior. Proton density-(PD) and T2-weighted images of postmortem-intact brains, up to 48 h after death, provided similar quality to ima...

Inherited canine copper toxicosis is a serious problem in Bedlington terriers and West Highland White terriers, and may also be a problem in other less-studied breeds. Affected dogs become ill at midlife with progressive and ultimately fatal liver disease. Treatments for removal of copper and prevention of copper accumulation are available, but are most effective if begun before the dog becomes...

By killing cattle and otherwise complicating management, the many species of larkspur (Delphinium spp.) present a serious, intractable, and complex challenge to livestock grazing management in the western United States. Among the many obstacles to improving our understanding of cattle-larkspur dynamics has been the difficulty of testing different grazing management strategies in the field, as t...

Introduction. The toxic nonprotein amino acid mimosine present in Leucaena leucocephala is degraded by rumen bacteria to produce another toxic compound, 3-hydroxy-4(lH)-pyridone (3,4-dihydroxypyridine, or 3,4-DHP). In some, but not all, geographic areas ruminants are colonized by bacteria that degrade 3,4-DHP, and actions of these microbes protect their host animals from leucaena toxicosis (Jon...