septic arthritis with polyarticular presentation is an uncommon clinical entity. a case of complicated staphylococcal infection with purulent and reactive polyarthritis, osteomyelitis, cutaneous and pleuropericardial involvement as well as transient blindness is presented here.

toxic shock syndrome in children following infection with influenza is a very rare syndrome. if it is not diagnosed quickly, it may cause significant morbidity and mortality. for diagnosis of toxic shock syndrome, clinical and laboratory criteria are used. our patient is a 3.5-year old boy who admitted to the hospital with high fever, weakness, toxicity, hypotension and skin rash due to influen...

toxic optic neuropathy (ton) is a group of medical disorders which can be defined by visual impairment due to optic nerve damage by a toxin. the exposure to a toxic substance can occur at the workplace, with ingestion of materials/ foods containing a toxin, or the use of systemic medications. ton is a disease entity which is not only under-diagnosed, but also often diagnosed at a stage when rec...

conclusions the nps-induced ots may increase the pro-inflammatory responses. on the other hand, administration of antioxidants such as nac and vitamin c and e prior to exposure to metal nps significantly decreases ots conditions. evidence acquisition here, a nanotechnology approach is evaluated using nps in human neuronal protection against ots. it may be wide therapeutic applications in the ca...

BACKGROUND Regions with abundant GC nucleotides, a high CpG number, and a length greater than 200 bp in a genome are often referred to as CpG islands. These islands are usually located in the 5' end of genes. Recently, several algorithms for the prediction of CpG islands have been proposed. METHODOLOGY/PRINCIPAL FINDINGS We propose here a new method called CPSORL to predict CpG islands, which...

There is growing evidence that micronutrient intake has a significant effect on the toxicity and carcinogenesis caused by various chemicals. This paper examines the effect of micronutrient status on the toxicity of four nonessential metals: cadmium, lead, mercury, and arsenic. Unfortunately, few studies have directly examined the effect of dietary deficiency or supplementation on metal toxicity...

over the past few decades, scientists have paid special attention to studying novel and natural hydrocolloids due to the growing demand for ready meals, public awareness on the importance of natural fibers in daily diets, and their wide range of application, especially in foods, pharmaceuticals and herbal medicine. moreover, natural hydrocolloids are preferred to biotechnologic ones (e.g., gell...

Artemisinin is a powerful antimalarial drug, useful in the treatment of many diseases, including chickens coccidiosis. Its toxic effects have been well studied humans and experimental animals, but not sufficiently broiler chickens. Therefore, present study, we aimed to assess side artemisinin chickens, by measuring serum level proteins enzymes (ALT, AST, GGT, ALP, CK), histopathological examina...

Alpha-synuclein (αSyn) plays a central role in the pathogenesis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). In sporadic PD and DLB, normally harmless αSyn proteins without any mutations might gain toxic functions by unknown mechanisms. Thus, it is important to elucidate the factors promoting the toxic conversion of αSyn, towards understanding the pathogenesis of and develop...

Antibiotics play a pivotal role in the management of infectious disease in humans, companion animals, livestock, and aquaculture operations at a global scale. Antibiotics are produced, consumed, and released into the environment at an unprecedented scale causing concern that the presence of antibiotic residues may adversely impact aquatic and terrestrial ecosystems. Here we critically review th...