The association between immunity and neurodevelopmental disorders has been extensively investigated in autism, suggesting a potential involvement of both cellular and humoral immunity in the establishment of synaptic connectivity modulation during development. A similar link has been proposed also for Tourette syndrome (TS), a complex, multifactorial disorder, in which the interplay between gen...

About 200 journal articles reported research on Tourette syndrome and other tic disorders in 2014. Here we briefly summarize a few of the reports that seemed most important or interesting, ranging from animal models to human studies. Readers can comment on our choices or provide their own favorites using the tools on the online article. This article is included in the channel. Tics 1

Background Tourette syndrome, first described in 1885, is a tic disorder differentiated from other movement disorders, such as myoclonic movements or transient tics of childhood. The median age at onset is seven years. In some cases, remissions occur or symptoms diminish. In other cases, the condition is lifelong. DSMIII-R diagnostic criteria are: multiple motor and one or more vocal tics prese...

This article presents highlights chosen from research that appeared during 2016 on Tourette syndrome and other tic disorders. Selected articles felt to represent meaningful advances in the field are briefly summarized. This article is included in the collection. Tics Kevin J. Black ( ) Corresponding author: [email protected] : Investigation, Writing – Original Draft Preparation, Writing – Review...

The cardinal characteristics of tic-related disorders are stereotyped motor movements and vocalizations. However, they may be accompanied by non-motor features that appear sequentially during the course of the disorder and can sometimes be more disabling than the tics themselves. This review presents our perspectives on several non-motor aspects of Tourette syndrome based on the long experience...

OBJECTIVE This is a review of progress made in the understanding of Tourette syndrome (TS) during the past decade including models of pathogenesis, state-of-the-art assessment techniques, and treatment. METHOD Computerized literature searches were conducted under the key words "Tourette syndrome," "Tourette disorder," and "tics." Only references from 1996-2006 were included. RESULTS Studies...

Heart of England NHS Foundation Trust, Birmingham, UK School of Life and Health Sciences, Aston Brain Centre, Aston University, Birmingham, UK Children’s Epilepsy Surgery Programme, The Birmingham Children’s Hospital NHS Foundation Trust, Birmingham, UK Department of Neuropsychiatry, Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham, UK Sobell Department of Motor Neuroscien...

1 I t is a striking observation that studies of copy number variation (CNV) in neurodevelopmental phenotypes continue to report an excess of rare variants in case populations. This astonishing esult has been observed and replicated in studies of intellectual isability (1), autism (2), schizophrenia (3), and epilepsy (4). In a tudy published this month in Biological Psychiatry, Tourette synrome ...