Staphylococcus xylosus is one of the major starter cultures used for meat fermentation because of its crucial role in the reduction of nitrate to nitrite which contributes to color and flavor development. Despite longstanding use of these additives, their impact on the physiology of S. xylosus has not yet been explored. We present the first in situ global gene expression profile of S. xylosus i...

BACKGROUND Given that YKL-40 is a known marker of inflammation, we sought to determine its association with urinary tract infection (UTI) in febrile children. METHODS In total, 44 children aged 0 to 24 months with febrile UTI and 35 age- and sex-matched controls with fever from other causes were enrolled in the study. ELISA was performed to determine the level of YKL-40 in urine collected fro...

OBJECTIVES The purpose of this study was to investigate the effects of ibuprofen on plasma nitrite/nitrate levels, as indirect indicators of nitric oxide, in correlation with blood pressure in a rabbit model of endotoxin-induced shock. METHODS A total of 28 rabbits were randomly divided into four groups. Control group received physiological saline, while endotoxin (ETX, E. Coli, 055:B5, 2 mg/...

Upregulation of xanthine oxidoreductase (XOR) increases vascular reactive oxygen species (ROS) levels and contributes to nitroso-redox imbalance. However, XOR can generate nitric oxide (NO) from nitrite, and increased superoxide could inactivate NO formed from nitrite. This study tested the hypothesis that XOR contributes to the cardiovascular effects of nitrite in renovascular hypertension, an...

RECENT EXPERIMENTAL EVIDENCE suggests that the anion nitrite represents an important storage form of nitric oxide (NO) that subsequently regulates a number of very important physiological activities (2–5, 10). This is a radical concept because nitrite was largely considered to be a biologically inert breakdown product of NO that served no physiological purpose. In fact, circulating nitrite leve...

This study evaluated the potential of two dried processing by products, obtained from large and cherry tomatoes (LT CT) after juice extraction to improve oxidative stability pork sausages during refrigerated storage for 20 days. For this purpose, reformulated nitrite-free were manufactured supplementation raw sausage samples with tomato byproducts (DLTB DCTB) at a dose that provides level polyp...

A long-term sodium nitrite infusion is intended for the treatment of vascular disorders. Phase I data demonstrated a significant nonlinear dose-exposure-toxicity relationship within the therapeutic dosage range. This study aims to develop a quantitative systems pharmacology model characterizing nitric oxide (NO) metabolome and methemoglobin after sodium nitrite infusion. Nitrite, nitrate, and m...

Nitrate serves as a potent signal to control gene expression in plants and algae, but little is known about the signaling role of nitrite, the direct product of nitrate reduction. Analysis of several nitrate-induced genes showed that nitrite increases mRNA levels as rapidly as nitrate in nitrogen-starved Arabidopsis (Arabidopsis thaliana) roots. Both nitrite and nitrate induction are apparent a...

Sodium nitrite, a common food additive, exists widely not only in the environment but also in our body. Excessive nitrite causes toxicological effects on human health; however, whether it affects vertebrate heart valve development remains unknown. In vertebrates, developmental defects of cardiac valves usually lead to congenital heart disease. To understand the toxic effects of nitrite on valvu...