BACKGROUND AND PURPOSE Increasing evidence suggests that inflammatory mechanisms are involved in the intracerebral hemorrhage-induced brain injury. We evaluated the prognostic role of the peripheral leukocyte counts and neutrophil-to-lymphocyte ratio (NLR) in patients with intracerebral hemorrhage. METHODS Patients with acute spontaneous intracerebral hemorrhage were retrospectively identifie...

Following preliminary in-vitro experiments, platelet-leukocyte conjugates and their determinants were evaluated in citrated whole blood from 349 subjects (209 women, age 16-92 years) randomly recruited from the general population. Platelet activation by ADP/collagen but not leukocyte stimulation by fMLP or LTB4 resulted in formation of platelet conjugates with PMN or monocytes. In the populatio...

Background: Dengue fever is an endemic disease in Nepal that has shown increasing incidence each passing year. a wide range of clinical presentations and laboratory findings. Thrombocytopenia common finding dengue-infected patients along with other findings like leukopenia, lymphocytosis, raised hematocrit, elevated liver enzymes. indicator severity can lead to severe bleeding manifestations. T...

In this prospective cohort study, we investigated the prevalence of Clostridium difficile-associated diarrhea (CDAD) in adult patients with nosocomial diarrhea by performing enzyme immunoassay (EIA) for detecting toxins A and B and polymerase chain reaction (PCR) for detecting the presence of the tcdB gene in stool samples. We determined the factors associated with CDAD, and the treatment o...

Background: Fatty liver disease has been associated with increased levels of various circulating inflammatory markers. Difference in the level markers between patients AFLD and NAFLD is still unclear. Aim & Objectives: The aim present study was to compare alcoholic-fatty (AFLD) non-alcoholic fatty (NAFLD) also see if any correlation exists enzymes. Materials Methods: This conducted on 70 (3...

IHRONIC GRANULOCYTIC LEUKEMIA is characterized by hepatosplenomegaly, a markedly elevated white blood cell count with a spectrum of immature and mature granulocytic elements present, a proliferative granulocytic bone marrow, low levels or absence of leukocyte alkaline phosphatase activity and the presence of the Philadelphia chromosome.’ The patient to be described had chronic granulocytic leuk...

Multiple Myeloma is a neoplasm of B cell lineage characterized by excessive proliferation of abnormal plasma cells. It is characterized by a clinical  pentad of 1) anemia, 2) a monoclonal protein in the serum or the urine or both, 3) bone leisons and or bone pain, 4) hypercalcemia >11.5g/dl and 5) renal insufficiency. Non secretory multiple myeloma is a rare variant of the classic form of multi...

Background: Mercury in any form is poisonous and mercury toxicity most commonly affects the nervous, gastrointestinal (GI) and urinary systems. The aim of this study was to investigate the specific effect associated with mercury toxicity and to evaluate the effectiveness of iron and vitamin B6 supplement on mercury-induced toxicities in rats. Methods: This experiment was performed on 25 rats...

The present study was designed to investigate the effect of folic acid on homocysteine, lipid profile and hematological changes in methionine-induced hyperhomocysteinemic rats. Hyperhomocysteinemia was induced by methionine (1 g/kg, p.o.) administration for 30 days. Biochemical and hematological observations were further substantiated with histopathological examination. The increase in homocyst...

Athletes are usually monitored by using biochemical and hematological indices for evaluating possible pathologies and performance status. The immunological response is constantly and periodically monitored by using various parameters, including C-reactive protein, total and specific immunoglobulins, and total leukocytes and their subsets. Athletes often suffer from immunological modifications a...