Floating matrix tablets of cefixime trihydrate were developed to prolong gastric residence time and to increase drug absorption and hence bioavailability. Hydrophilic polymers viz. HPMC K4M and Xanthan gum were incorporated in varied proportions to develop floating matrix tablets of cefixime by direct compression method. Buoyancy was achieved by adding an effervescent mixture of sodium bicarbon...

Famotidine has been the most widely used drug for the treatment of peptic ulcer for many decades. The present investigation concerns the development and evaluation of floating tablets of famotidine which, after oral administration, are designed to prolong the gastric residence time, increase drug bioavailability and target the gastric ulcer. A floating drug delivery system (FDDS) was developed ...

The polyhedra abstract domain is one of the most powerful and commonly used numerical abstract domains in the field of static program analysis based on abstract interpretation. In this paper, we present an implementation of the polyhedra domain using floating-point arithmetic without sacrificing soundness. Floating-point arithmetic allows a compact memory representation and an efficient impleme...

In the recent high speed processor, floating point ALU (FP ALU) is one of the important units to perform the arithmetic and logical functions of the floating point number. Floating point multiplication is one of the arithmetic operations that take more computational time and when implemented in hardware, it requires more area due to the large number of component. However the advantage of implem...

The design and implementation of a double precision floating-point IEEE-754 standard adder is described which uses “flagged prefix addition” to merge rounding with the significand addition. The floating-point adder is implemented in 0:5 m CMOS, measures 1:8mm2, has a 3-cycle latency and implements all rounding modes. A modified version of this floating-point adder can perform accumulation in 2-...

Metoprolol succinate (MS) gastroretentive (GR) controlled release system was formulated to increase gastric residence time leading to improved drug bioavailability. Box-Behnken model was followed using novel combinations of sodium alginate (SA), sodium carboxymethylcellulose (NaCMC), magnesium alumino metasilicate (MAS) as independent variables. Floating lag time (Flag), t25, t50, t75, diffusio...

The resonance of a floating tension leg platform (TLP) excited by the third-harmonic force of a regular wave is investigated based on fully nonlinear theory with a higher order boundary element method (BEM). The total wave elevation and the total velocity potential are separated into two parts, based on the incoming wave from infinity and the disturbed potential by the body. A numerical radiati...

Petascale computing is currently a common topic of discussion in the high performance computing community. Biological applications, particularly protein folding, are often given as examples of the need for petascale computing. There are at present biological applications that scale to execution rates of approximately 55 teraflops on a special-purpose supercomputer and 2.2 teraflops on a general...

this study was performed to design bilayer regioselective floating tablets of atenolol and lovastatin to give immediate release of lovastatin and sustained release of atenolol. bilayer floating tablets comprised two layers, i.e immediate release and controlled release layers. the immediate release layer comprised sodium starch glycollate as a super disintegrant and the sustained release layer c...

The execution performances of the Sweeney, Robertson, Tocher (SRT) division algorithm depend on two parameters: the radix and the redundancy factor. In this paper, a study of the effect of these parameters on the division performances is presented. At each iteration, the SRT algorithm performs a multiplication by the quotient digit .This last can be just a simple shift, if the digit is a power ...