AIMS Glucose transporter 10 (GLUT10), encoded by the SLC2A10 gene, is a member of the class III facilitative glucose transporter family. Mutations in the SLC2A10 gene cause arterial tortuosity syndrome (ATS) in humans. To further study the pathogenesis of the disease, we generated mice carrying GLUT10 mutations. METHODS AND RESULTS Using a gene-driven N-ethyl-N-nitrosourea (ENU)-mutagenesis a...

BACKGROUND The dilation of veins and tortuosity of arteries that occur in retinopathy of prematurity (ROP) are improved by therapy, and thus posttherapy changes in ocular circulation are also conceivable. We report a case of ROP in which we were able to measure the ocular circulation before and after photocoagulation therapy, using a laser speckle flowgraphy (LSFG) system that is modified for n...

BACKGROUND Women with non-ST elevation myocardial infarction (NSTEMI) have similar extent of myocardial ischemia but less obstructive coronary artery disease (CAD) than their male counterparts. We tested the impact of global coronary artery plaque area and artery tortuosity on myocardial perfusion in NSTEMI patients. METHODS Coronary artery plaque area was determined by quantitative angiograp...

This article describes the case of a 10-year-old girl with generalized tortuosity and lengthening of all her major arteries-the carotid arteries, the aorta from the arcus to the bifurcation, and the iliac, femoral, splenic, hepatic, renal, and intercostal arteries. The condition appears to be a new entity. Pertinent abnormalities were as follows: gross pulsation of the arteries in the neck, tel...

Giant coronary artery aneurysm is rare. A 71-year-old female was referred to our hospital 3 months after onset of symptoms. Work-up including coronary angiogram and computed tomographic angiogram helped a definite diagnosis of a giant aneurysm of the circumflex coronary artery. The patient was conservatively managed with a close follow-up. In this article, this rare lesion was presented with as...

3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med. 2007;13(7):868-873. 7. Koto T, Nagai N, Mochimaru H, et al. Eicosapentaenoic acid is antiinflammatory in preventing choroidal neovascularization in mice. Invest Ophthalmol Vis Sci. 2007;48(9):4328-4334. 8. Mukherjee PK, Marcheselli VL, Barreiro S, Hu J, Bok D, Bazan NG. Neurotrophins enhance retinal pigment epithe...

BACKGROUND AND PURPOSE In some patients with stenosis of an intracranial artery, navigating the balloon or stent-delivery system is difficult of tortuous anatomy of the aortic arch, carotid arteries, or vertebral arteries Our purpose was to describe techniques of intracranial stent placement that help in navigating the stent-delivery system in tortuous vessels. METHODS Between May 1998 and Ju...