Objective The study objective was to examine the association between phentermine/topiramate therapy and weight loss adverse events in adults with overweight or obesity by meta-analysis systematic review. Methods Medical Subject Headings free-text terms were selected search for eligible trials PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Embase up April 18, 2020. quality ran...

Topiramate infrequently induces anion gap metabolic acidosis through carbonic anhydrase inhibition on the distal tubule of the nephron--a type 2 renal tubular acidosis. We report on a 40 years old woman previously healthy that developed significant asymptomatic metabolic acidosis during topiramate therapy at a dosage of 100 mg/day for three months. Stopping medication was followed by normalizat...

The case of a 20 year old female presenting with overnight acute loss of vision is reported. The patient was recently started on topiramate (Hitop) for her recurrent migraine and developed sudden loss of vision due to acute myopia. Topiramate was discontinued and the patient's vision returned to normal. Delayed and incorrect treatment may result in permanent vision loss, secondary to angle clos...

Topiramate is a broad-spectrum antiepileptic medication that is used as monotherapy or in combination with other medications to treat epilepsy in both adults and children. It is also indicated for migraine prophylaxis in adults. An off-label use of topiramate is as a mood stabilizer (with no associated weight gain) in rapid-cycling and mixed bipolar episodes. The mechanisms of action of topiram...

Background Neuropathic pain is one of the most common complaints of neurologic clinics. Neuropathic pain is common and important and has inappropriate complications, and despite their importance, there is no effective treatment for them. Objective Because of the importance of neuropathic pain and safe and effective treatment, in this study, we determined the effect of topiramate versus gabape...

this study was designed to assess the effect of five common anticonvulsant drugs on naloxone-precipitated withdrawal syndrome in morphine-dependent mice. male mice (25-35 g) were made dependent by increasing doses of morphine (30-90 mg/kg). at least three doses of phenytoin, carbamazepine, sodium valproate, lamotrigine and topiramate were injected i.p. to morphine-dependent mice 45 min prior to...

We present a case of topiramate-induced angle-closure glaucoma that was treated with cycloplegia. A 40-yearold woman with a history of migraine presented with bilateral acute onset of blurred vision and headache. She had been prescribed 50 mg of oral topiramate bid for migraine prophylaxis 10 days prior to her presentation. On her ocular examination visual acuity was 20/20 with a myopic correct...

The authors report a 51-year-old women with pharmacoresistant partial epilepsy who tolerated well valproate monotherapy and in combination with several other antiepileptic drugs, but developed symptoms and signs of reversible hepatic failure under a combination of valproate and topiramate. Symptoms resolved after discontinuation of VPA. This case provides further anecdotal evidence that topiram...