Topical dexamethasone responsiveness was determined in a group of 56 volunteer prison inmates. Drops were administered to each volunteer four times daily, thus eliminating the factor of patient reliability in use of the medication. The findings fit closely a prevalence of 0.25 for the steroid responder gene in the general population. An increased prevalence of nontasters to phenylthiocarbamide ...

PURPOSE To describe a patient with Thygeson's superficial punctate keratitis successfully treated with long-term cyclosporin A. CASE PRESENTATION A 15-year-old boy presented with long-term ocular symptoms of foreign body sensation, burning, irritation, tearing, and transient photophobia. One year's treatment with steroidal agents had led to only partial improvement. Clinical and laboratory ev...

Allergic rhinitis is a common disease with a lifetime prevalence of 20% among the United States population. The cost of medication alone to manage allergic rhinitis in the United States was estimated to be $3.1 billion. The two most commonly prescribed classes of medications are antihistamines and topical nasal steroids. The data on comparing the efficacy of a commonly used antihistamine (azela...

AIM To determine whether use of a topical, nonsteroidal, anti-inflammatory, and anti-itching formula was able to preserve the absence of symptoms, mainly itching and burning, induced by an earlier and relatively short treatment with topical steroids in women diagnosed with vulvar dermatitis or lichen simplex. METHODS Ninety-six subjects (36 with contact dermatitis, 29 with allergic dermatitis...

3. Nussenblatt RB, Palestine AG. CsA: immunology, pharmacology and therapeutic uses. Surv Ophthalmol. 1986;31:159-169. 4. Costabel U. Sarcoidosis: clinical update. Eur Respir J Suppl. 2001;32(suppl):S56-S68. 5. Baughman RP, Lower EE. Steroid-sparing alternative treatments for sarcoidosis. Clin Chest Med. 1997;18:853-864. 6. Holland EJ, Olsen TW, Ketcham JM, et al. Topical cyclosporin A in the t...

BACKGROUND Toxic epidermal necrolysis (TEN) is a rare systemic allergic drug eruption with high patient mortality. Currently, no established treatments have been shown to be effective for TEN beyond supportive care. Prior studies of systemic corticosteroids have yielded conflicting data, with some showing a possible benefit and others reporting in increased mortality. However, topical steroids ...

Circumcision is traditionally performed for persistent phimosis in boys. Although there continues to be a considerable debate over the merits of circumcision, it is clear that preservation of the pediatric foreskin even in the presence of phimosis is a viable option. Prepuce spontaneously separates from the glans as the age increases and true phimosis is rare in children(1). Prepuce develops an...

Purpose To report two new cases of presumed erlotinib-associated bilateral acute simultaneous-onset anterior uveitis effectively treated with topical steroids. Observations Two patients were referred to the uveitis clinic with bilateral acute simultaneous onset, anterior uveitis six weeks after starting the chemotherapeutic agent erlotinib. Frequent topical steroid were started and the inflam...

This review aims to summarize evolving evidence on topical steroid (TS) therapy for eosinophilic esophagitis (EoE). Currently, we still use "off-label" TS, originally designed for bronchial or intranasal delivery. Direct oral administration (i.e., oral viscous budesonide) achieves better histological results than the aerosolized swallowed route, due to longer mucosal contact time. High-dose flu...

Introduction: Acute skin wound healing is a complicated process comprising various phases. Recent animal studies have shown that steroid sex hormones such as estrogen maybe helpful in the regulation of several pathophysiologic stages that are involved in wound healing. In this study we examined the effects of topical estrogen in the treatment of traumatic facial wounds.   Materials and Methods:...