The oral retention of fluoride (F) following the topical application of a newly developed APF foam was compared with a conventional APF gel. Twenty adults aged 16-26 years participated in the study. Ten of the subjects received the F foam and gel treatments, on separate occasions, with a saliva ejector while another 10 subjects received the same treatment without saliva ejector. Approximately 4...

The anti-inflammatory activity of Achillea and Ruscus extracts was studied in comparison with diclofenac sodium topical gel (diclosal Emulgel), using the carrageenan induced paw edema model in Albino rats. Gel formulation was prepared containing 6% of each extract in gel base, namely sodium carboxymethylcellulose (NaCMC). The kinetics of drug release from the prepared formulation was studied se...

Background: Minoxidil has been reported to inhibit in vitro fibroblast proliferation and lysyl hydroxylase activity, a key enzyme in collagen biosynthesis. These in-vitro effects proposed minoxidil to be a potential antifibrotic agent. The present study aimed to investigate the effects of minoxidil gel on wound healing procedure in a second-degree burn model in rats.  Materials and methods: Wis...

BACKGROUND Heel prick blood sampling is a commonly performed and painful procedure in the newborn infant. Use of a topical local anaesthetic does not relieve this pain. A 4% w/w amethocaine gel (Ametop) reduces the pain of venepuncture in the newborn but has not been tried with heel pricks. AIM To investigate the effect of topical amethocaine gel on the pain of heel prick in the newborn infan...

Pyoderma gangrenosum (PG) is the most severe of all cutaneous extraintestinal manifestations seen in inflammatory bowel diseases. PG is more common in women than in men, predominantly affects the lower limbs and is usually ulcerative.1 Prednisone and cyclosporine have been mainstays of systemic treatment for PG, although increasing evidence supports the use of biologic therapies, such as tumor ...

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The purpose of this study was to compare the oral fluoride (F) retention following acidulated phosphate fluoride (APF) foam and gel applications in children. Fifty-nine children were divided into two groups, 6-9 years old and 10-13 years old. They each received a randomly assigned sequence of topical F foam and gel applications in two consecutive visits, using either sponge-lined or unlined tra...

BACKGROUND Acute ankle sprains are common and activity limiting injuries, and topical diclofenac gel has proven efficacy in alleviating pain and restoring function. This trial aimed to compare a topical natural agent, Traumeel with topical diclofenac gel (1%) in the management of acute ankle sprain. METHODS This prospective, multicentre, randomised, blinded, active-control and non-inferiority...

The aim and objective of the study was to develop herbal drug loaded niosomes as topical gel by using thin film hydration technique. The practicability of herbal drug (CODE: THDC3-2615RD) of niosomes by thin film hydration technique using Span series 20, 60, 80 and cholesterol has been successfully revealed in this study. The evolved herbal niosomes were evaluated for morphology, particle size ...