One of the causes of permanent disability in chronic multiple sclerosis patients is the inability of oligodendrocyte progenitor cells (OPCs) to terminate their maturation program at lesions. To identify key regulators of myelin gene expression acting at the last stages of OPC maturation we developed a drug repositioning strategy based on the mouse immortalized oligodendrocyte (OL) cell line Oli...

BACKGROUND Erosive lichen planus (ELP) affecting mucosal surfaces is a chronic autoimmune disease of unknown aetiology. It is often more painful and debilitating than the non-erosive types of lichen planus. Treatment is difficult and aimed at palliation rather than cure. Several topical and systemic agents have been used with varying results. OBJECTIVES To assess the effects of interventions ...

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous adverse involving multiorgan failure, complex interaction of various drugs, human herpesvirus reactivation immune abnormalities suggested as the aetiology. We herein present case 70-year-old man one-week history fever, facial oedema, erythematous macules purpura on his trunk extremities. He had anti-TIF1γ antibo...

Abstract A 35-year-old woman presented with a 4-year history of persistent pruritic rash affecting her upper and lower limbs, concerning to the patient for cosmetic reasons. She denied any precipitating factors reported no improvement use topical clobetasol propionate. Notably, mother had similar rash, which also developed in 30s continued progress over time. Physical examination revealed bilat...

Keloids are benign dermal fibroproliferative neoplasms that occur at sites of cutaneous injury as a result of abnormal wound recovery. They are characterized by excess accumulation of extracellular matrix with thickened and disorganized collagen bundles. Unlike normal scar tissue, keloids do not regress and may extend beyond the confines of the original wound (1). Although the exact etiology of...

Sir, Nail psoriasis affects 20–55% of psoriatic patients. It often represents a significant cause of distress because of the visible lesions and the chronic course of the disease. Treatment options include corticosteroids, vitamin D3 analogues, 5-fluorouracil, urea, anthralin, cyclosporine and radiotherapy (1). Tazarotene is an acetylenic retinoid with documented therapeutic results in skin pso...

Abstract A 43-year-old woman presented with a 3-year history of gradually enlarging lesion on the right upper chest. Her comorbidities included ankylosing spondylitis and recurrent anterior uveitis, she was taking no regular medications. She had systemic symptoms. initially seen by breast team, who organized an ultrasound that showed chronic inflammation, biopsy granulomatous inflammatory tissu...