In this study, we did a bioassay employing mice with a dominant-negative p53 mutation (p53(Val135/WT)) to assess whether a germ-line p53 mutation predisposed mice toward the development of squamous cell carcinomas (SCC) in the oral cavity. Treatment of the mouse oral cavity with 4-nitroquinoline-1-oxide produced a 66%, 91%, and 20% tumor incidence in the oral cavity, esophagus, and forestomach/...

<p class="abstract"><strong>Background:</strong> There is paucity of published data on head and neck tumours (HNTs) in Ghana, even the few studies available were conducted middle southern belts country. The present study northern was to histopathological characteristics HNTs offer recommendations.</p><p class="abstract"><strong>Methods:</strong> This re...

During the past decades, an increased incidence of squamous cell carcinoma (SCC) of the tongue in young adults has been reported in several countries [1-4]. Some researches stated that male-to-female ratio was lower in young adults than in mature adults. Unlike the elder patients, many of young subjects had never used tobacco or over consumed alcohol. However, the time of exposure to these well...

objectives: geographic tongue or migratory glossitis is an inflammatory disorder with unknown etiology. considering the accompanied burning pain, taste dysfunction, and lack of definite cure, it is important to treat this condition symptomatically. the objective of the current study was to compare the efficacy of a combination of 0.05% retinoic acid and 0.1% triamcinolone acetonide with that of...

Background: The purpose of this study was to determine the value of CT or MR imaging in demonstrating benign, malignant, congenital and iatrogenic mass lesions of the tongue. Although the vast majority of tongue masses are squamous cell carcinomas, a variety of unusual lesions may affect the tongue. Thus the characteristics and extent of these unusual lesions may be recognized only on cross sec...