Dendritic cells (DCs) from NOD mice produced high levels of IL-12 that induce IFNγ-producing T cells involved in diabetes development. We propose to utilize the microorganism ability to induce tolerogenic DCs to abrogate the proinflammatory process and prevent diabetes development. NOD DCs were stimulated with Lactobacilli (nonpathogenic bacteria targeting TLR2) or lipoteichoic acid (LTA) from ...

Acute, low dose ultraviolet B radiation of murine body wall skin followed by local application of DNFB produces a state of antigen-specific unresponsiveness. This state is maintained at least in part by an Lyt-1+ T cell that effects unresponsiveness by impairing the induction phase of contact hypersensitivity. The absence of suppressor cells capable of acting at the effector stage of immunity s...

DCs are innate immune cells that play a central role in linking innate and adaptive immunity, as they are potent, professional APCs with the unique ability to prime naive T cells in vivo. On the other hand, DCs are also critical in the maintenance of immune tolerance against self-antigens to prevent the development of autoimmunity [1]. Indeed, tolerogenic DCs endowed with immunoregulatory funct...