Several studies have demonstrated that nitric oxide (NO) is involved in hyperalgesia induced by NMDA activity in Morphine tolerance and NO synthase inhibitors can attenuate hyperalgesia in morphine tolerance. In addition, one of the possible mechanisms in morphine tolerance is reduction of GABA inhibitory effect. For this reason, we used GABA agonists (muscimol and baclofen) to investigate the ...

the map and the model designed by a designer and presented to a manufacturer in the form of a map is the result of his knowledge and innovation. the manufacturer, in turn, uses his best effort to produce a part accordingly. however, because of production problems and raw material, producing a precise part is very difficult and costly. one of the most important problems in this regard is designi...