Currently there is no cure for Alzheimer's disease (AD); clinical trials are underway to reduce amyloid generation and deposition, a neuropathological hallmark in brains of AD patients. While genetic factors and neuroinflammation contribute significantly to AD pathogenesis, whether increased cholesterol level is a causative factor or a result of AD is equivocal. Prenylation of proteins regulati...

Tocotrienols are a subclass of vitamin E compounds that display potent anticancer activity. Determining the anticancer mechanism of action of tocotrienols will provide essential information necessary for understanding the potential health benefits of these compounds in reducing the risk of breast cancer in women. Epidermal growth factor (EGF) is a potent mitogen for normal and neoplastic mammar...

Tissue-specific accumulation of tocopherols and tocotrienols in turkey tissues during embryonic development and their susceptibility to lipid peroxidation were investigated. Fertile turkey eggs were incubated using standard commercial conditions. Embryonic tissues were collected at 16, 22, 25 d of incubation and from day-old poults (referred to as day 29) and alpha-; beta- + gamma- and delta-to...

Introduction The incidence of dengue fever (DF) has increased 30 fold between 1960 and 2010 [1]. The literature suggests that temperature plays a major role in the life cycle of the mosquito vector and in turn, the timing of DF outbreaks [2]. We use real-time data from GDT and real-time temperature estimates from NASA Earth observing systems to examine the relationship between dengue and climat...

Two common measures of auditory temporal resolution are the temporal modulation transfer function (TMTF) and the gap detection threshold (GDT). The current study addresses the lack of efficient psychophysical procedures for collecting TMTFs and the lack of literature on the comparisons of TMTF and GDT. Two procedures for efficient measurements of the TMTF are proposed: (1) A Bayesian procedure ...

Tortuosity is defined as the ratio of the actual path length from start to goal through the pores to the Euclidean distance (shortest linear distance). However, traditional methods to calculate tortuosity, such as the calculation of tortuosity out of the results from dissolution experiments, do not determine path length directly. In this paper we describe the application of image analysis for d...