نتایج جستجو برای: tobramycin

تعداد نتایج: 2629  

Journal: :Critical Care 2004
Gunilla Goscinski Miklos Lipcsey Mats Eriksson Anders Larsson Eva Tano Jan Sjölin

INTRODUCTION Antibiotics used for treatment of severe bacterial infections have been shown to exert effects on the inflammatory response in addition to their antibacterial effects. The aim of the present study was to investigate whether the biological effects of endotoxin in a porcine model could be neutralized by tobramycin, and whether tobramycin or ceftazidime was able to modulate the inflam...

Journal: :Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2001
M Y Desrosiers M Salas-Prato

OBJECTIVE To study the efficacy of nebulized topical saline-tobramycin solution in patients with chronic rhinosinusitis refractory to medical and surgical therapy. STUDY DESIGN AND SETTING Twenty patients in whom endoscopic sinus surgery failed to relieve symptoms entered a randomized, double-blind trial of tobramycin-saline solution or saline-only solution administered thrice daily to the na...

2018
Nusaiba K. Al-Nemrawi Nid’’A H. Alshraiedeh Aref L. Zayed Bashar M. Altaani

(1) Background: Poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with Tobramycin were prepared using a solvent-evaporation method. (2) Methods: The NPs were coated with low molecular weight chitosan (LMWC) to enhance the mucoadhesiveness of PLGA-NPs. The following w/w ratios of tobramycin to LMWC were prepared: control (0:0.50), F₀ (1:0.25), F₀.₅ (1:0.5), and F₁ (1:1). (3) Result...

Journal: :Investigative ophthalmology & visual science 1988
D S Rootman J A Jantzen J R Gonzalez M J Fischer R Beuerman J M Hill

Transcorneal iontophoresis of tobramycin in normal eyes of New Zealand white rabbits was compared to an eye cup control and application of fortified topical drops. Iontophoresis was performed with 25 mg/ml of tobramycin at 0.8 mAmps for 10 or 5 min. The eye cup with 25 mg/ml of tobramycin was placed on the eye for 10 min without current. Topical fortified drops (13.6 mg/ml) were applied every h...

Journal: :Clinical chemistry 1983
P M Kabra P K Bhatnagar M A Nelson J H Wall L J Marton

We describe a simple, precise, accurate, and specific liquid-chromatographic procedure for determination of tobramycin in 50 microL of serum. Tobramycin and the internal standard (sisomicin) are quantitatively converted into their trinitrophenyl derivatives by reaction with a water-soluble derivatizing agent (2,4,6-trinitrobenzenesulfonic acid) at 70 degrees C for 30 min. The derivatives are ex...

Journal: :Antimicrobial agents and chemotherapy 2015
Philip S Stewart Michael J Franklin Kerry S Williamson James P Folsom Laura Boegli Garth A James

Enhanced tolerance of biofilm-associated bacteria to antibiotic treatments is likely due to a combination of factors, including changes in cell physiology as bacteria adapt to biofilm growth and the inherent physiological heterogeneity of biofilm bacteria. In this study, a transcriptomics approach was used to identify genes differentially expressed during biofilm growth of Pseudomonas aeruginos...

Journal: :Orthopedics 2012
Lige Kaplan Michael Kurdziel Kevin C Baker James Verner

Antibiotics are commonly mixed with polymethylmethacrylate (PMMA) cement to suppress severe periprosthetic infections associated with total joint arthroplasty. The relationship between antibiotic concentration and the resulting elution kinetics remains unclear. The purpose of this study was to characterize the release of daptomycin from PMMA cement and the subsequent effects on mechanical prope...

Journal: :The Journal of antimicrobial chemotherapy 2012
Louise D Christensen Maria van Gennip Tim H Jakobsen Morten Alhede Hans Petter Hougen Niels Høiby Thomas Bjarnsholt Michael Givskov

OBJECTIVES Quorum sensing (QS)-deficient Pseudomonas aeruginosa biofilms formed in vitro are more susceptible to tobramycin than QS-proficient P. aeruginosa biofilms, and combination treatment with a QS inhibitor (QSI) and tobramycin shows synergistic effects on the killing of in vitro biofilms. We extended these results to an in vivo P. aeruginosa foreign-body biofilm model. The effect of trea...

2015
Bastiaan HJ Wittekamp Evelien AN Oostdijk Anne Marie GA de Smet Marc JM Bonten

INTRODUCTION Selective decontamination of the digestive tract (SDD) and selective oropharyngeal decontamination (SOD) have been shown to improve intensive care unit (ICU) patients' outcomes. The aim of this study was to determine the effects of long-term use of SDD and SOD on colistin and tobramycin resistance among gram-negative bacteria. METHODS We performed a post hoc analysis of two conse...

Journal: :The Journal of antimicrobial chemotherapy 2008
Judy N Chin Ronald N Jones Helio S Sader Paul B Savage Michael J Rybak

OBJECTIVES Previous data from our research had shown that the novel ceragenin, CSA-13, demonstrated concentration-dependent bactericidal activity against glycopeptide-resistant Staphylococcus aureus. However, it is unknown whether CSA-13 demonstrates a similar property against Pseudomonas aeruginosa. We evaluated CSA-13 antipseudomonal activity compared with cefepime, meropenem, piperacillin/ta...

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