The IL-6/STAT3 and TNFα/NFκB pathways are emerging as critical mediators of inflammation-associated colon cancer. TNF receptor (TNFR) 2 expression is increased in inflammatory bowel diseases, the azoxymethane/dextran sodium sulfate (AOM/DSS) model of colitis-associated cancer, and by combined interleukin (IL) 6 and TNFα. The molecular mechanisms that regulate TNFR2 remain undefined. This study ...

BACKGROUND/AIM Tumour necrosis factor-α (TNFα) is an inflammatory cytokine that is upregulated in various vitreoretinal diseases including uveitis and diabetic retinopathy. Recently, our studies have indicated that hyalocytes contribute to the pathogenesis of these diseases. However, the impact of TNFα on the functional properties of hyalocytes is unknown. METHODS Hyalocytes were isolated fro...

The study aimed to describe the effectiveness of switching the anti-TNFα agent when an acceptable clinical response has not been obtained with the first anti-TNFα agent in patients with uveitis in VKH syndrome. Patients diagnosed with VKH syndrome being evaluated from the uveitis unit of a single tertiary hospital from January 1, 2000, to October 30, 2015. Patients who presented uveitis with an...

The cytokine, tumor necrosis factor α (TNFα), is a key regulator of neuroinflammation linked to numerous neurodegenerative conditions and diseases. The present study used transgenic rats that overexpress a murine TNFα gene, under the control of its own promoter, to investigate the impact of chronically elevated TNFα on hippocampal synaptic function. Neuronal viability and cognitive recovery in ...

This paper constructs fully parallel NN hardware architecture, FPGA has been used to reduce neuron hardware by design the activation function inside the neuron without using lookup table as in most researches, to perform an efficient NN. It consist of two main parts; the first part covers network training using MATLAB program, the second part represents the hardware implementation of the traine...

ةـصلاخلا : ةلاحلا رايعم ثحبلا اذه يف ضرعن – ةلاحلا حشرمُــل لماشلا يبراقتلا تابثلل غارفلا – يمقرلا غارفلا عبشملا يباسحلا ضئافلا مادختساب كلذو ةددحم ةميق اذ . دقو ماظنلل ةديدج ةيصاخ ءاصقتساب رايعملا قُـتشأ ةساردلا ديق . اس رايعم عم رايعملا اذه ةنراقمب انمق امآ جنيسو راآ نم لٍآ لَـبـقِ نم هضرع مت قب . دقو جنيسو راآ رايعم نم لقأ طباوض يذ يلاحلا رايعملا نأ ةنراقملا تنابأ . و نع حرتقملا رايعملا ةعاجن ان...

INTRODUCTION Several studies have reported that TNFα is substantially increased within skin lesions of patients with discoid lupus erythematosus (DLE), subacute cutaneous lupus erythematosus (SCLE) and dermatomyositis (DM) compared to controls. Elevated TNFα has been reported in the sera of some patients with systemic lupus erythematosus, DLE and SCLE, but not in the sera of patients with DM. B...

INTRODUCTION Adalimumab is a fully human anti-tumor necrosis factor α (anti-TNFα) monoclonal antibody that specifically blocks the interaction of TNFα with its receptors. It binds both soluble and transmembrane TNFα. We hypothesized that blocking these TNFα signals regulates the altered TNFα production in rheumatoid arthritis (RA) patients. METHODS We compared, by flow cytometry, Toll-like re...

TNFα and IL-1β are two proinflammatory cytokines that play critical roles in many diseases, including rheumatoid arthritis and infectious diseases. How TNFα- and IL-1β-mediated signaling is finely tuned is not fully elucidated. Here, we identify tripartite-motif protein 38 (TRIM38) as a critical negative regulator of TNFα- and IL-1β-triggered signaling. Overexpression of TRIM38 inhibited activa...