Two proteases produced by the SARS-CoV-2 virus, main protease and papain-like protease, are essential for viral replication have become focus of drug development programs treatment COVID-19. We screened a highly focused library compounds containing covalent warheads designed to target cysteine identify new lead scaffolds both Mpro PLpro proteases. These efforts identified small number hits no v...

Abstract The severity of the new COVID-19 pandemic caused by SARS-CoV-2 virus is strikingly variable in different global populations. uses ACE2 as a cell receptor, TMPRSS2 protease, and FURIN peptidase to invade human cells. Here, we investigated 1,378 whole-exome sequences individuals from Middle Eastern populations (Kuwait, Qatar, Iran) explore natural variations...

Influenza A viruses (IAVs) are a major cause of infectious respiratory human diseases and their transmission is dependent upon the environment. However, the role of environmental factors on IAV survival outside the host still raises many questions. In this study, we used lentiviral pseudotypes to study the influence of the hemagglutinin protein in IAV survival. High-titered and cleaved influenz...

Recently, a contagious lung disease named coronavirus 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2), rapidly spread worldwide and has many serious consequences for human health. Human genetic polymorphisms may contribute to the variation of incidence, mortality as well severity COVID-19. To date, this factor in Vietnamese population remains unknown. A cellular prote...

SARS-CoV-2 rapidly spread worldwide and resulted in an unprecedented pandemic. Considering the novelty of this disease, its potential effects on endocrine system remain elusive. This virus is known to utilize extracellular domain angiotensin-converting enzyme (ACE) transmembrane protein TMPRSS2. Broad expression ACE-2 TMPRSS2 a cause extrapulmonary manifestations SARSCoV- 2, including ones. The...

Our previous study demonstrated that an extract of Cordyceps militaris (CM) derived from Samia Cynthia ricini inhibits testosterone-induced prostate hypertrophy in animal model. However, the bioactive components CM modulate function cells have not been identified and characterized. To do this, present explored effective component(s) influences viability androgen-responsive LNCaP cancer androgen...

Prostate cancer is the most common solid tumor among men in Western industrialized countries. A major problem in prostate cancer treatment is the development of androgen-independence, as androgen-deprivation therapy is the basic therapy for the disease. Molecular mechanisms behind prostate cancer and androgen-independent growth development are poorly known. In this study, subtractive hybridizat...