Tenascin-C (TNC) is a large hexameric extracellular matrix glycoprotein that is expressed in developing organs and tumors. It has been reported that TNC is expressed in inflamed synovial membranes and deformed discs of temporomandibular joint (TMJ) disorder. However, the role of TNC in TMJ is not fully known. In this study, the role of TNC in fibrous adhesion formation of TMJ was examined using...

Purpose: To investigate the relation between temporomandibular joint (TMJ), pain and anterior open bite versus TMJ structional changes Materials and Methods: Sixty-four patients, 18 men and 46 female, with TMJ involvement of rheumatoid arthritis (RA) were included. 20 healthy patients were included as controls. A clinical examination performed regarding TMJ pain, tenderness to palpation and the...

OBJECTIVE To determine the prevalence and features of temporomandibular joint (TMJ) arthritis by magnetic resonance imaging (MRI) among children with juvenile idiopathic arthritis (JIA), and to identify risk factors for TMJ arthritis. METHODS A retrospective chart review was performed on 187 patients with JIA who underwent a TMJ MRI at Children's Hospital of Alabama between September 2007 and...

Recent recognition of the markedly high prevalence of temporomandibular joint (TMJ) arthritis in children with juvenile idiopathic arthritis (JIA) coupled with the significant morbidity associated with TMJ damage has prompted increased interest in both the clinical and pathological aspects of TMJ arthritis. This review focuses on the prevalence of TMJ arthritis in JIA, the imaging modalities us...

Temporomandibular disorder (TMD) is a generic term used for any problem concerning the jaw joint. Injury to the jaw, temporomandibular joint, or muscles of the head and neck can cause TMD. Other possible causes include grinding or clenching the teeth, which puts a lot of pressure on the TMJ; dislocation of the disc; presence of osteoarthritis or rheumatoid arthritis in the TMJ; stress, which ca...

Trigeminal pain represents one of the worst pains that humans can suffer. One of the obstacles towards development of rationally targeted therapies is rooted in shortcomings of available animal models for trigeminal pain. Another roadblock is lack of clear understanding of molecular and cellular mechanisms that underlie this type of pain. TRPV4 is a polymodally activated Ca-permeable nonselecti...

Temporomandibular disorders are a form of musculoskeletal disorders, which reduce the function of stomatognathic system and they are related to some other diseases causing painful conditions and disorders of oral function. The aim of this paper is to describe a one year follow up clinical case of a female patient with comorbid multiple sclerosis and a relatively rare form of articular disc diso...

Trauma is the predominant causal factor for temporomandibular joint (TMJ) ankylosis. However, the relationship between condylar fracture and TMJ ankylosis is complicated. It is believed that post-traumatic TMJ ankylosis arises from TMJ intracapsular changes, including damaged cartilage, displaced or disrupted discs, haematoma formation and subsequent fibrosis and calcification in the joint. In ...

Purpose: to assess the prevalence of temporomandibular disorders among dental undergraduate Egyptian students and association between clinical features radiographic findings. Material Methods: 281 female were randomly selected participate in primary screening. In study screening examination final diagnosis done according a new modified Diagnostic Criteria for TMD (DC/TMD) Axis I which encompass...

The present study was designed to test the hypothesis that estrogen exacerbates inflammation of the temporomandibular joint (TMJ). Evans blue dye was used to quantify plasma extravasation (PE) around the rat TMJ. In an initial set of experiments, TMJ PE was compared in naïve intact male and female rats, as well as in both groups after complete Freund's adjuvant (CFA)-induced inflammation of the...