Tick-transmitted zoonoses such as human granulocytic anaplasmosis (HGA), Lyme borreliosis and tick-borne encephalitis (TBE) are endemic in several European countries, including Slovenia. Ixodes ricinus, the most prevalent species of hard ticks in Slovenia, is the principal vector for Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and TBE virus [1]. Information on clinically manifest...

In 1997, ticks removed from humans and received alive by the Tick-Borne Disease Laboratory of the U.S. Army Center for Health Promotion and Preventive Medicine (USACHPPM) were tested for pathogens by polymerase chain reaction (PCR). Thirty-three of 222 (15%) Amblyomma americanum (L.) DNAs produced amplicons of the expected size of Ehrlichia chaffeensis Anderson, Dawson & Wilson and 26/222 (12%)...

The association between companion animals and tick-borne rickettsial disease has long been recognized and can be essential to the emergence of rickettsioses. We tested whole blood from dogs in temporary shelters by using PCR for rickettsial infections. Of 93 dogs, 12 (13%) were positive for Rickettsia parkeri, an emerging tick-borne rickettsiosis.

Eight fatal cases of tick-borne encephalitis with an unusual hemorrhagic syndrome were identified in 1999 in the Novosibirsk Region, Russia. To study these strains, we sequenced cDNA fragments of protein E gene from six archival formalin-fixed brain samples. Phylogenetic analysis showed tick-borne encephalitis variants clustered with a Far Eastern subtype (homology 94.7%) but not with the Siber...

Differentiation of endemic East African tick-borne relapsing fever Borrelia duttonii spirochetes from epidemic louse-borne relapsing fever (LBRF) B. recurrentis spirochetes into different species has been questioned. We assessed a noncoding intragenic spacer (IGS) region to compare genotypes found in clinical samples from relapsing fever patients. Although IGS typing was highly discriminatory a...

Tick-borne encephalitis (TBE) and Lyme borreliosis (LB) are tick-borne diseases (TBDs), and both present an increasing burden worldwide. Vaccination as public health intervention could be the most effective way to reduce this burden. TBE vaccines are available, but vaccines against LB are still in the phase of development. At the European level, TBE vaccines are likely under-administered to eff...

....................................................................................................................................................... 1 Populärvetenskaplig sammanfattning ........................................................................................................ 3 List of papers .........................................................................................

Blacklegged ticks, Ixodes scapularis, can transmit single or multiple infections during a tick bite. These tick-borne, zoonotic become chronic and cause insidious diseases in patients. In the present tick-pathogen study, 138 (48.9%) of 282 ticks collected from 17 sites 6 geographic area eastern Canada harbored various combinations Borrelia burgdorferi sensu lato (Lyme disease), Anaplasma phagoc...

since the mid-19 th century, human activities have increased greenhouse gases such as carbon dioxide, methane, and nitrous oxide in the earth's atmosphere that resulted in increased average temperature. the effects of rising temperature include soil degradation, loss of productivity of agricultural land, desertification, loss of biodiversity, degradation of ecosystems, reduced fresh-water resou...