When CY-treated mice were given sheep red blood cells the serum hemagglutinin titers produced were significantly lower than those found when mice received SRBC but not CY. Titers could be raised to the levels found in the latter group if, in addition to SRBC, the CY-treated mice received 2 x 10(7) normal syngeneic spleen cells or a mixture containing 1.2 x 10(8) normal thymus and 1.2 x 10(8) no...

OBJECTIVE To study the changes of the center of cellular immune thymus and the interference of Jinhong Tablet, a compound traditional Chinese herbal medicine, during the course of cholangitis. METHODS Twenty-four male Wistar rats were randomly divided into three groups. Ligation group, simple ligation of bile duct without producing infection and fed with normal saline; untreated group, reprod...

an abnormally large thymus gland in itself cannot be considered to be indicative of status thymicolymphaticus when no obvious cause of death is found at post mortem. On the other hand, Moncrieff (1938) has remarked that an enlarged thymus is not a common chance finding .in .the chests of infants who have been z-rayed for other conditions, of heart or lungs. Also a study of a number of healthy i...

Dear Editor, Thymus and inferior parathyroids usually develop from the third pharyngeal pouch around the sixth foetal week. The inferior parathyroids separate from the thymic tissue and remain close to lower pole of the thyroid, while the thymus descends into the mediastinum. During thymic migration, small fragments of thymus may separate and attach themselves to any site along this route. Para...

Ligature of the cervical lymph duct in guinea pigs resulted in marked dilatation of the lymphatics draining the thymus and marked reduction of mitosis in the thymus. A decrease of about 50% in the number of mitoses was found in the cortex within one day after ligation and in the medulla within five days after ligation. The thickness of the cortex also decreased rapidly and markedly in direct pr...

Thymus transplants can correct deficiencies of the thymus epithelium caused by the complete DiGeorge syndrome or FOXN1 mutations. However, thymus transplants were never used to correct T cell-intrinsic deficiencies because it is generally believed that thymocytes have short intrinsic lifespans. This notion is based on thymus transplantation experiments where it was shown that thymus-resident ce...

An inverse relation exists between melatonin and androgen in most of the seasonally breeding rodents, but the regulation of their receptors in modulation of immune function has never been reported. The present study accessed the expression pattern of melatonin receptor types (mt1R & mt2R), immune parameters (lymphoid organs weight, leucocyte count, delayed type hypersensitivity and lymphocyte p...

The effect of physiological and pharmacologically induced thymus involution was studied in 12-week-old female C57BL mice. Thymus involution was estimated by measurement of the thymus weight and the ability of thymocytes to induce a graft-versus-host (GvH) reaction at 48 h after delivery or drug administration in comparison with control (virgin, saline-treated) mice. The thymus weight and immuno...

AIMS Electromagnetic fields (EMFs) can act as inducers or mediators of stress response through the production of heat shock proteins (HSPs) that modulate immune response and thymus functions. In this study, we analyzed cellular stress levels in rat thymus after exposure of the rats to a 2.45 GHz radio frequency (RF) using an experimental diathermic model in a Gigahertz Transverse Electromagneti...