Essential thrombocythemia (ET) is a clonal stem cell disease characterized by isolated thrombocytosis and thrombohemorrhagic complications. We describe an unusual case of ET primarily presenting with skin symptoms including erythromelalgia and livedo reticularis (racemosa-type). Persistent thrombocytosis, bone marrow findings, JAK2 gene mutation, and markedly decreased ristocetin-cofactor activ...

BACKGROUND Incidences of colorectal cancer (CRC) and inflammatory bowel disease (IBD) are increasing in those aged <50 years. AIM To identify and quantify clinical features in primary care of CRC/IBD in those aged <50 years. This study considered the two conditions together and aimed to determine which younger patients, presenting in primary care with symptoms, would benefit from investigatio...

M.L. Randi, F. Fabris, C. Vio, A. Girolami, University of Padua, Institute of Medical Semeiotics, Via Ospedale, 105‚ I-35100 Padua (Italy) Several instances of familial polycythemia vera (PV) have been described [1,6, 9]; however, no data are available on the incidence of primary or secondary thrombocytosis in the same family. Over the last 10 years we have studied 170 subjects with thrombocyto...

SIR, In their interesting abstract on platelets and rheumatoid arthritis' Farr et al. call attention to the frequent presence of an inflammation-related thrombocytosis in rheumatoid arthritis (RA). They point out that such a finding is not specific of RA. In fact they found thrombocytosis related to disease activity also in patients affected with Crohn's disease. We reached the same conclusions...

This thesis is based on the following publications which will be referred to in the text by their Roman numerals (I-V). Some additional unpublished results are presented. evaluation and presence of positive diagnostic findings.

Thrombocytosis is occasionally seen in patients with carcinomas and has been assumed to be attributable to interleukin-6 or granulocyte-macrophage colony-stimulating factor produced by carcinoma cells. In this study, we clarified whether thrombopoietin (TPO) is involved in carcinoma-associated thrombocytosis. Expression of TPO mRNA was observed in the majority of 27 carcinoma cell lines as dete...

OBJECTIVE It has earlier been suggested that postoperative thrombocytosis frequently occur after coronary artery bypass grafting (CABG) and may be linked to lipid disturbances. A prospective randomized study was undertaken to evaluate if preoperative lipid-control, using HMG-CoA-reductase inhibitor (Zocor), simvastatin, reduces the risk of postoperative thrombocytosis. METHODS Seventy-seven p...