We describe a multi-scale, liver-centric in silico modeling framework for acetaminophen pharmacology and metabolism. We focus on a computational model to characterize whole body uptake and clearance, liver transport and phase I and phase II metabolism. We do this by incorporating sub-models that span three scales; Physiologically Based Pharmacokinetic (PBPK) modeling of acetaminophen uptake and...

We consider a variety of nearest-neighbor spin models defined on the d-dimensional hypercubic lattice Z. Our essential assumption is that these models satisfy the condition of reflection positivity. We prove that whenever the associated mean-field theory predicts a discontinuous transition, the actual model also undergoes a discontinuous transition (which occurs near the mean-field transition t...

This paper presents the harmonic state space (HSS) modeling of a three-phase modular multilevel converter (MMC). MMC is a converter system with a typical multi-frequency response due to its significant harmonics in the arm currents, capacitor voltages, and control signals. These internal harmonic dynamics can have a great influence on the operation characteristics of MMC. However, the conventio...

Atomic commitment protocols are used to ensure the atomicity of atomic transactions. The best known and most widely used atomic commitment protocol is two phase commit (2PC). The main idea behind 2PC is to perform two rounds of voting under the guidance of a site acting as coordinator. The coordinator asks first for votes on whether to commit (yes vote) or abort (no vote) the transaction. The p...

Distributed database systems use commit protocols to ensure atomicity in case of distributed transactions and a wide variety of commit protocols have been proposed so far. Two–phase commit (2PC) is a widely accepted standard protocol for distributed transactions. But 2PC suffer from blocking problem due to which three-phase commit (3PC) protocol was proposed which is an extension of 2PC. This p...

This paper presents a novel distribution power flow algorithm to estimate losses and analyze unbalanced distribution systems. An unbalanced distribution network is decomposed into clusters. The unbalanced laterals are solved using the backward/forward sweep method in each phase. The clustering of total network makes faster computation. The three phase modeling of all the distribution transforme...