The use of the tetrahydropyranyl (Thp) group for the protection of serine and threonine side-chain hydroxyl groups in solid-phase peptide synthesis has not been widely investigated. Ser/Thr side-chain hydroxyl protection with this acid-labile and non-aromatic moiety is presented here. Although Thp reacts with free carboxylic acids, it can be concluded that to introduce Thp ethers at the hydroxy...

This paper provides upper and lower bounds on the information rates achievable with a minimum mean square error (MMSE) Tomlinson-Harashima precoder (THP) assuming ideal interleaving. We also give an exact formula for zero-forcing (ZF) THP achievable information rates. At high SNR, the performance of the MMSE-THP and the ZF-THP identically suuer only the 2.55 bit or 1.53 dB \shaping" loss from c...

?.j fId' region. It was completely covered by skin thp tu?TG waj? thick black hair over about half ihnnt ,T,top *he head was flat and only Thp nl?;i j an ,'n above the supra-orbital margios; hut thr> Wa-S a'.lve an^ the heart was beating normally Thp Ph^S5-ra,tlons were somewhat slower than usu3'* intn th + about 12 hoUrs after birth. Incis^ rprphrr, !! ? S,ur., showed it to contain mening^ thp...

This re~Pa rch is supported hy thP Ad,·ancPd RPsParch Projects Agency under Contract :\o. DAHClS 67 C 011-l. Views or concluE<ions contained in this study should not be interpreted as representing the official opinion or policy of ARPA. · DISTRIBUTION ST ATEJ\IENT This document has been approved for public release and sale; its distribution is unlimited.This Rand Memorandum is presented as a co...

Absolute total cross section (TCS) for electron scattering from tetrahydropyran (THP: (CH2)5O) molecules has been measured from 1 to 400 eV, using a linear electron transmission technique. The TCS energy function for electron–THP collisions is characterized by the broad enhancement spanned between 3 and 15 eV, which can be attributed to resonant processes. Comparison is also made between the pr...

In a previous study we noted significant THP binding to TNF-α, but did not explore the molecular basis of the structure-binding relationship. In this study, we used lectin-binding ELISA to assess the carbohydrate compositions of THP, BSA, IgG, TNF-α, and IFN-g. We identified β(1,4)-N-acetylglucosamine oligomers (GlcNAc) and GlcNAc/branched mannose in BSA, IgG, TNF-α, and THP, but not in IFN-g. ...

UNLABELLED BACKGROUND The primary, stable metabolite of nicotine [(S)-3-(1-methyl-2-pyrrolidinyl) pyridine] in humans is cotinine [(S)-1-methyl-5-(3-pyridinyl)-2-pyrrolidinone]. We have previously shown that cotinine exposure induces convergence and amplification of the GSK3β-dependent PI3 kinase and cholinergic anti-inflammatory systems. The consequence is reduced pro-inflammatory cytokine ...

Relapse to drug use is often cited as the major obstacle in overcoming a drug addiction. Whereas relapse can occur for a myriad of reasons, it is well established that complex neuroadaptations that occur over the course of addiction are major factors. Cocaine, as a potent dopamine transporter blocker, specifically induces alterations in the dopaminergic as well as other monoaminergic neurotrans...

The present study was designed to evaluate the neuroprotective effect of Erythropoietin (EPO) in brain of memory impaired mice. Memory impairment was produced by THP in different groups of animals. Morris water maze (MWM) and Elevated plus maze (EPM) test was employed to assess learning and memory. At the end of study brain anticholinesterase (AchE) activity was estimated. Administration of EPO...

Polybutadiene and a co poly mer consisting of 76.5 percent butadiene and 23 .5 percent of styrene were investigated as to t he rates of t heir t hermal degradation . The ra tes for polybu tadiene indicated an act iv:ttion energy of 60 kilocalories per mole. The copolym er had very high init ial rates of degradation, followed by a rapid cirop, so t hat it wa~ not possible to obtain a reliab le a...