Specific aims of this study are to investigate the mechanism governing surface stress generation associated with chemical or molecular binding on functionalized microcantilevers. Formation of affinity complexes on cantilever surfaces leads to charge redistribution, configurational change and steric hindrance between neighboring molecules resulting in surface stress change and measureable cantil...

BACKGROUND Arsenic (As) toxicity is primarily based on its chemical speciation. Although inorganic and methylated As species are well characterized in terms of metabolism and formation in the human body, the origin of thiolated methylarsenicals is still unclear. OBJECTIVES We sought to determine whether sulfate-reducing bacteria (SRB) from the human gut are actively involved in the thiolation...

Partially thiolated polycytidylic acid (MPC), an antileukemic agent, when administered to leukemic RF/UN mice inhibited the clonogenicity of bone marrow progenitor cells in a time- and dose-dependent manner. The effect of a single dose of MPC disappeared within 40 hr due to the rapid degradation of this compound in mice. When MPC was encapsulated in liposomes before injection, its activity at 1...

In recent decades, three generations of thiomers have been developed with the main purpose obtaining enhanced interactions mucosal tissues. Therefore, many different types thiolated ligands generated and attached to polymeric backbones. The aim this study was synthesize all directly compare their properties regarding mucus penetration mucoadhesion. Starting from pectin, unprotected thiomer pect...