Monitoring of thiopurine metabolites is important due to a complex metabolism with large interindividual variation, but the suitability of currently used methods has been questioned. The drawbacks include poor reproducibility, the inability to differentiate between the different analytes, as well as the use of a nontarget matrix. Further research should be directed toward measuring thiopurine m...

The incorporation of 6-thioguanine (S6G) into DNA is a prerequisite for its cytotoxic action, but duplex structure is not significantly perturbed by the presence of the lesion [J. Bohon and C. R. de los Santos (2003) Nucleic Acids Res., 31, 1331-1338]. It is therefore possible that the mechanism of cytotoxicity relies on a loss of stability rather than a pathway involving direct structural reco...

The theory and practice of Ayurveda are based on the doctrine of tridosa, according to which disease states spring from the disturbance of the three factors vata, pitta and kapha. Being a wholistic medical system Ayurveda considers several variables in the diagnosis and treatment of diseases. This report identifies these variables in detail and highlights their clinical significance.

of Indian philosophy is that man is a microcosm of the macrocosmic world that he inhabits. This implies explicitly that whatever man is made up of, the world too is made up of those same things or elements, but with different combinations and degrees. Here, by elements is meant the five mahabhutasthat is Akasa, Vayu, Tejas, Ap and Prithvi. (Ether, air, fire, water and earth proto-elements respe...

The primary objective of this review is to synthesize the existing literature on the use of animal-assisted therapy and activity (AAT/A) as complementary treatment among people living with chronic disease and to discuss the possible application of this practice among children living with HIV. Relevant databases were searched between March 10 and April 11, 2011, using the words: animal assisted ...