نتایج جستجو برای: thiazolidine 4 ones
تعداد نتایج: 1407163 فیلتر نتایج به سال:
The electrochemical behaviors of thiazolidine (tetrahydrothiazole) on gold and platinum electrodes were investigated in a Britton-Robinson buffer (pH 2.77-11.61), acetate buffer (pH 4.31), phosphate buffer solutions (pH 2.11 and 6.38) and methanol or acetonitrile containing various supporting electrolytes. Detection was based on a gold wire electrochemical signal obtained with a supporting elec...
Fluoroquinolones with pyrrolidinyl substitutions were tested against Trypanosoma brucei and mammalian cells. Bulky substituents at C-7 or a 1-2-bridging thiazolidine ring increased antitrypanosomal activity and selective toxicity. These compounds trap protein-DNA complexes and inhibit nucleic acid biosynthesis in trypanosomes, characteristics of topoisomerase II inhibition.
A series of N-substituted thiazolidine-2,4-dione derivatives bearing potentially bioactive substituents were synthesized by microwave irradiation method. Structural elucidation was accomplished by 1H NMR, 13C NMR, IR, Mass and elemental analyses. The synthesized compounds were evaluated for antimicrobial activities. Among the compounds studied, compounds 4i and 4d showed potent antimicrobial ac...
The effect of various proline analogs on proline oxidation in mitochondria isolated from etiolated barley (Hordeum vulgare) shoots was investigated. Of the analogs tested, only l-thiazolidine-4-carboxylic acid (T4C) was an effective inhibitor. T4C (1 millimolar) inhibited proline (10 millimolar) -dependent 0(2) uptake an average of 67%. T4C was also oxidized to some degree (12.9 nanoatoms oxyge...
This paper describes a simple means for embedding a checksum within a FITS header, providing a mechanism for later verifying the integrity of the FITS le. The method uses ASCII coded 32-bit 1's complement arithmetic to force the checksum of each FITS HDU to zero. This technique requires no extension of the FITS standard to be used by any given project, in fact the technique may be used to zero ...
The second author’s ω, ∆, χ conjecture proposes that every graph satisties χ ≤ d 1 2 (∆ + 1 + ω)e. In this paper we prove that the conjecture holds for all claw-free graphs. Our approach uses the structure theorem of Chudnovsky and Seymour. Along the way we discuss a stronger local conjecture, and prove that it holds for claw-free graphs with a three-colourable complement. To prove our results ...
We modified the thiazolidinic ring at positions N3, C4, and C5, yielding compounds 6-24. Compounds with a phenyl at position N3, 15-19, 22-24, exhibited better inhibitory properties for cruzain and against the parasite than 2-iminothiazolidin-4-one 5. We were able to identify one high-efficacy trypanocidal compound, 2-minothiazolidin-4-one 18, which inhibited the activity of cruzain and the pro...
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