OBJECTIVES To test the application of statistical methods to detect data fabrication in a clinical trial. SETTING Data from two clinical trials: a trial of a dietary intervention for cardiovascular disease and a trial of a drug intervention for the same problem. OUTCOME MEASURES Baseline comparisons of means and variances of cardiovascular risk factors; digit preference overall and its patt...

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................................................................................................................... 8 Résumé ................................................................................................................... 10 Introduction........................................................................................................... 12 Motivation of research ..........