Most respiratory practitioners agree that PEEP helps to recruit and maintain alveoli that would otherwise collapse or suffer tidal inflation and deflation. PEEP thus reduces atelectrauma, shear forces, and systemic inflammatory mediator release. These benefits are balanced against consequences. PEEP can lead to overdistention of lung units, especially those that remain normal in the midst of he...

The aim of this study was to evaluate manual nasal continuous positive airway pressure (nCPAP) titration during daytime polysomnography compared with conventional overnight titration for patients with severe obstructive sleep apnoea. Thirty-two patients who underwent daytime titration were retrospectively matched (for age, sex, body mass index and apnoea/hypopnoea index (AHI)) to a group titrat...

The esterification of galacturonic acid with methanol and/or acetic is important for the structural analysis pectin. Although several methods have been reported determining degree methylesterification (DM) and acetylation (DAc), present study compares optimizes three (titration, FT-IR HPLC) using commercial citrus pectin (CP). Our results showed that DM CP was 47.0%, 47.6% 48.0% as determined b...

Heat dissipation is one of the most serious problems in modern integrated electronics with continuously decreasing devices size. Large portion consumed power inevitably dissipated form waste heat which not only restricts device energy-efficiency performance itself, but also leads to severe environment and energy crisis. Thermoelectric Seebeck effect a green energy-recycling method, while thermo...

Different forms of titration curves obtained by ELISA for serum antibodies, monoclonal antibodies and polyreactive immunoglobulins were considered. A new interpretation of dose-dependent titration curves was suggested. It was shown that our interpretation of dose-dependent titration curves for antibodies which are presented in some biological liquids allow obtaining additional information about...

TOPIC: Sleep Disorders TYPE: Original Investigations PURPOSE: Solriamfetol (Sunosi®) is a dopamine/norepinephrine reuptake inhibitor approved (US and EU) to treat excessive daytime sleepiness (EDS) in adults with narcolepsy (75-150 mg/d) or obstructive sleep apnea (OSA) (37.5-150 mg/d). Titration strategies for hypothetical patient were analyzed understand factors physicians consider when initi...

BACKGROUND Levodopa-carbidopa intestinal gel (LCIG; Duodopa®) is used for continuous infusion in advanced Parkinson's disease. To achieve optimal effect, the LCIG dose is individually titrated, traditionally conducted during hospitalization in Sweden. However, dose adjustment depends on surrounding conditions, physical activity, and emotional stress, which is why titration at home could be bene...